{"id":"W3008637313","doi":"10.1534/genetics.119.302851","title":"Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development","year":2020,"lang":"en","type":"article","venue":"Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Biology; Proteases; CRISPR; Protease; Genetic screen; Bacillus subtilis; Escherichia coli; Proteome; Microbiology; Staphylococcus aureus; Mutant; Bacteria; Genetics; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043409,0.0003251217,0.0002430736,0.0001727395,0.0001034365,0.0003506988,0.0002257629,0.0002514516,0.0007525051],"category_scores_gemma":[0.00009039325,0.0001297677,0.0002200343,0.0001277878,0.0001414662,0.0002067625,0.0001937942,0.0004518459,0.0004386653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002964731,"about_ca_system_score_gemma":0.0001679198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000159387,"about_ca_topic_score_gemma":0.0003074788,"domain_scores_codex":[0.9999112,0.00001375007,0.000008912509,0.00001545929,0.00003385836,0.00001683473],"domain_scores_gemma":[0.9999151,0.00001075918,0.00002904623,0.00001419439,0.00001399978,0.00001685802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007467069,0.00002155921,0.0001534101,0.00002708505,0.000003532992,0.00008115413,0.000005132729,0.0001949162,0.9958274,0.0002396368,0.00008299462,0.003288402],"study_design_scores_gemma":[0.00002458729,0.0002794918,0.001089271,0.000006197851,0.00001220379,0.0003984085,0.00001247547,0.001500007,0.9879221,0.00009994653,0.008649793,0.000005350933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9513509,0.007020898,0.03295954,0.0004848565,0.0001120805,0.0001258272,0.001047636,0.0007476069,0.006150659],"genre_scores_gemma":[0.9796739,0.002217323,0.01481897,0.00008124352,0.00001893477,0.00004069526,0.000750911,0.00003428578,0.002363807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007525051,"threshold_uncertainty_score":0.002517402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03551624890419721,"score_gpt":0.2712522834456755,"score_spread":0.2357360345414783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}