{"id":"W3008637313","doi":"10.1534/genetics.119.302851","title":"Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development","year":2020,"lang":"en","type":"article","venue":"Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Biology; Proteases; CRISPR; Protease; Genetic screen; Bacillus subtilis; Escherichia coli; Proteome; Microbiology; Staphylococcus aureus; Mutant; Bacteria; Genetics; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007575875,0.0001427494,0.0001284813,0.00001014041,0.0001130777,0.00004794755,0.0001707694,0.00007670196,0.00000636185],"category_scores_gemma":[0.00002109902,0.0001112748,0.00005156806,0.00005357466,0.00005182022,0.000001361529,0.000154648,0.00005584243,0.000002991833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001093871,"about_ca_system_score_gemma":0.0002090378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005493002,"about_ca_topic_score_gemma":0.00001397407,"domain_scores_codex":[0.9991266,0.00001932716,0.0001683628,0.0003425015,0.000114002,0.0002292823],"domain_scores_gemma":[0.9994644,0.00001064385,0.0000615899,0.0002500327,0.00005158889,0.0001617335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000176767,0.00002678357,0.0005331486,0.0000388461,0.0001100552,9.281816e-7,0.000185002,0.00003866319,0.9765188,0.0001531649,0.001853455,0.02036435],"study_design_scores_gemma":[0.0006752555,0.0002631732,0.0009497342,0.000009350586,0.00003347773,0.000003577176,0.0000291089,0.000263621,0.7087874,0.0001354796,0.2887011,0.0001485935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9360736,0.003183223,0.05189217,0.007284116,0.0002102397,0.001208036,0.00001985427,0.00002033823,0.0001084299],"genre_scores_gemma":[0.9813215,0.0005505954,0.01427458,0.002932799,0.000600373,0.00002810673,0.00002977524,0.00002938988,0.0002328759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2868477,"threshold_uncertainty_score":0.4537657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03551624890419721,"score_gpt":0.2712522834456755,"score_spread":0.2357360345414783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}