{"id":"W3008656988","doi":"10.1016/j.plefa.2020.102078","title":"LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells","year":2020,"lang":"en","type":"article","venue":"Prostaglandins Leukotrienes and Essential Fatty Acids","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Moncton; Université Laval; Institut Universitaire de Cardiologie et de Pneumologie de Québec","funders":"Canadian Institutes of Health Research; New Brunswick Innovation Foundation; Canada Research Chairs; Heart and Stroke Foundation of Canada; Fondation de la recherche en santé du Nouveau-Brunswick","keywords":"Arachidonate 5-lipoxygenase; THP1 cell line; Cell culture; CD14; Molecular biology; Biology; Immune system; Monocytic leukemia; Leukotriene; Lipopolysaccharide; Chemistry; Endocrinology; Biochemistry; Immunology; Enzyme; Arachidonic acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008972683,0.0001983362,0.0002946056,0.0001333958,0.0001781251,0.00009328646,0.00004734501,0.000119081,0.00007490419],"category_scores_gemma":[0.0000417677,0.0001627069,0.00004989849,0.0002053816,0.00007011044,0.0002840841,0.0000901514,0.0002562657,0.000004094469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003445342,"about_ca_system_score_gemma":0.00004460712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009237746,"about_ca_topic_score_gemma":0.000008794492,"domain_scores_codex":[0.9988514,0.00003397151,0.0003064157,0.0004026313,0.0001716037,0.0002340151],"domain_scores_gemma":[0.999498,0.00002959947,0.00008880471,0.0001254794,0.00004945632,0.0002086355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003179326,0.0001060466,0.0131146,0.0001847466,0.00002446596,0.00002522878,0.001678412,0.000008790179,0.9830461,0.00005309443,0.0000941158,0.001346484],"study_design_scores_gemma":[0.002197891,0.0004586454,0.01359436,0.0002397859,0.00005049794,0.00002209378,0.0003969596,0.000946069,0.9801853,0.00005693264,0.001658419,0.0001930349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967221,0.0001583567,0.00122514,0.001080672,0.00008655983,0.0004907974,0.00001780922,0.00005564588,0.0001629308],"genre_scores_gemma":[0.9988573,0.0001334977,0.0002838668,0.0002638019,0.0002858298,0.0000325533,0.00007923847,0.00002359252,0.00004036717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002860773,"threshold_uncertainty_score":0.6634994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02932661542935653,"score_gpt":0.2789205578549825,"score_spread":0.249593942425626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}