{"id":"W3008656988","doi":"10.1016/j.plefa.2020.102078","title":"LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells","year":2020,"lang":"en","type":"article","venue":"Prostaglandins Leukotrienes and Essential Fatty Acids","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Moncton; Université Laval; Institut Universitaire de Cardiologie et de Pneumologie de Québec","funders":"Canadian Institutes of Health Research; New Brunswick Innovation Foundation; Canada Research Chairs; Heart and Stroke Foundation of Canada; Fondation de la recherche en santé du Nouveau-Brunswick","keywords":"Arachidonate 5-lipoxygenase; THP1 cell line; Cell culture; CD14; Molecular biology; Biology; Immune system; Monocytic leukemia; Leukotriene; Lipopolysaccharide; Chemistry; Endocrinology; Biochemistry; Immunology; Enzyme; Arachidonic acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002462338,0.0004151901,0.0002859914,0.0005479781,0.0003910165,0.0005323123,0.0001203834,0.0002792996,0.004151039],"category_scores_gemma":[0.0001763749,0.0002106586,0.0004640792,0.0003799273,0.0003034585,0.0002235627,0.0003952128,0.0007339609,0.001250561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003784293,"about_ca_system_score_gemma":0.0004077762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001561016,"about_ca_topic_score_gemma":0.001637897,"domain_scores_codex":[0.9995777,0.00006825542,0.00003295427,0.00004857402,0.00008334818,0.0001891666],"domain_scores_gemma":[0.9998583,0.00003368654,0.00002024168,0.00001662401,0.00002407955,0.0000471137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001028252,0.0001262887,0.0005830572,0.00006094627,0.000006657385,0.0001708347,0.00008539586,0.00004755725,0.9962808,0.0001736464,0.0001433416,0.00129323],"study_design_scores_gemma":[0.00012372,0.0009369248,0.01958814,0.00002271049,0.00002980924,0.0002791572,0.0004597035,0.001060632,0.972046,0.0001522787,0.00528828,0.00001260689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907324,0.001502019,0.003195128,0.0003025575,0.0001141018,0.00005862012,0.00165159,0.00008954174,0.002353939],"genre_scores_gemma":[0.9879913,0.000784698,0.001834242,0.0001912697,0.00006709903,0.00009827231,0.003204462,0.00001498147,0.00581377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004151039,"threshold_uncertainty_score":0.01388663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02932661542935653,"score_gpt":0.2789205578549825,"score_spread":0.249593942425626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}