{"id":"W3008667379","doi":"10.1016/j.celrep.2020.01.099","title":"Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Indian Council of Medical Research; Department of Science and Technology, Ministry of Science and Technology, India; National Institutes of Health; Novartis","keywords":"Visceral leishmaniasis; Leishmania donovani; Immune system; Immunology; Immunity; Leishmania; Biology; Leishmaniasis; Interferon; Parasitic disease; Parasite hosting; Disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003550427,0.0002625445,0.0002520178,0.000188834,0.00009909421,0.0002886359,0.0001348362,0.0003039965,0.002033851],"category_scores_gemma":[0.0002507819,0.00006304304,0.0001875691,0.0001288539,0.0002098907,0.0001679223,0.0001356043,0.0007475014,0.00037011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00014947,"about_ca_system_score_gemma":0.0001743143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001334327,"about_ca_topic_score_gemma":0.0002831673,"domain_scores_codex":[0.9998714,0.00004789891,0.000008749208,0.00001327547,0.00003492169,0.00002380342],"domain_scores_gemma":[0.99989,0.00002465722,0.0000423346,0.00001100514,0.0000145313,0.00001752161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0013812,0.0004251772,0.002674161,0.0006643511,0.00009571022,0.0001984486,0.00005077826,0.0002787361,0.8412788,0.002105846,0.003223787,0.1476232],"study_design_scores_gemma":[0.0009719825,0.008777585,0.02382948,0.0003789953,0.0003693292,0.002758784,0.0002028439,0.001374174,0.8285192,0.003264618,0.1295231,0.00002996702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7611985,0.1791524,0.0205769,0.007105773,0.002039701,0.0002817173,0.00110842,0.0005605249,0.027976],"genre_scores_gemma":[0.9511899,0.03592288,0.004269062,0.001602698,0.0004271703,0.000128101,0.0005556822,0.00003626341,0.005868217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002033851,"threshold_uncertainty_score":0.00680393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03574606518751005,"score_gpt":0.3044760298092869,"score_spread":0.2687299646217768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}