{"id":"W3008699822","doi":"10.1101/2020.02.26.965269","title":"A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Cancer Council NSW; Natural Sciences and Engineering Research Council of Canada; Center of Excellence for Innovation in Chemistry; Kids Cancer Alliance; Cancer Institute NSW","keywords":"Telomerase; Telomere; Förster resonance energy transfer; Ribonucleoprotein; G-quadruplex; Chemistry; DNA; RNA; Telomerase RNA component; Resolution (logic); Biophysics; Stereochemistry; Crystallography; Telomerase reverse transcriptase; Biology; Biochemistry; Fluorescence; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001814202,0.0002591167,0.0002198494,0.0001168643,0.0001806688,0.0002575284,0.0003027416,0.0005532678,0.0009605098],"category_scores_gemma":[0.0002605454,0.0002189636,0.0002609797,0.00006760089,0.0002980525,0.0003859839,0.0001753567,0.0005042115,0.0003339365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002402639,"about_ca_system_score_gemma":0.0001810003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001799674,"about_ca_topic_score_gemma":0.0001349003,"domain_scores_codex":[0.9999417,0.000007417011,0.000003398139,0.00002537679,0.00001214092,0.000009887108],"domain_scores_gemma":[0.9999079,0.00002589904,0.00002820576,0.00001675756,0.000007115507,0.00001402483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005408064,0.00003188175,0.000438485,0.00004314145,0.000009781627,0.0001485244,0.00003030075,0.001342864,0.9944128,0.001356518,0.00009528016,0.002036358],"study_design_scores_gemma":[0.00002852668,0.0001478904,0.0009783758,0.000005715355,0.00001019531,0.0002242101,0.0000236338,0.01721261,0.9786602,0.001048991,0.001645764,0.00001392694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724415,0.0006815822,0.02512115,0.0002581279,0.00004349354,0.00004433755,0.0001096902,0.0002870615,0.001013015],"genre_scores_gemma":[0.984314,0.000339834,0.01355332,0.00008176817,0.00001302089,0.00004064657,0.0001137342,0.00001588726,0.001527738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009605098,"threshold_uncertainty_score":0.003213167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586019471078841,"score_gpt":0.2271800234174343,"score_spread":0.2113198287066459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}