{"id":"W3008712021","doi":"10.3389/fphar.2020.00077","title":"Sphingosine-1-Phosphate Receptors Modulators Decrease Signs of Neuroinflammation and Prevent Parkinson’s Disease Symptoms in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model","year":2020,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Neuroinflammation; Parkinson's disease; Sphingosine-1-phosphate receptor; Pharmacology; Receptor; Sphingosine-1-phosphate; Chemistry; Sphingosine; MPTP; Medicine; Disease; Neuroscience; Internal medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003786006,0.0002301846,0.0003132409,0.0001128618,0.00004927642,0.00001474986,0.0003209084,0.0001177026,0.00001356184],"category_scores_gemma":[0.0001906786,0.0002046783,0.00008583598,0.0002389717,0.0001327137,0.00001966441,0.0001106844,0.0002092683,5.386576e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001941883,"about_ca_system_score_gemma":0.0001088909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002112817,"about_ca_topic_score_gemma":0.00000361012,"domain_scores_codex":[0.9983235,0.0002844033,0.0004400645,0.000468523,0.0001636578,0.0003198671],"domain_scores_gemma":[0.9993354,0.00002695046,0.0001632745,0.0001962155,0.00003421384,0.0002439111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00100586,0.0001995355,0.02214539,0.00009788696,0.00006690974,0.00001606692,0.001014694,0.0624124,0.9066758,0.00004517086,0.004678544,0.001641786],"study_design_scores_gemma":[0.003697839,0.0002688899,0.002754006,0.00002147164,0.0001850305,0.000003146953,0.0002454601,0.3399154,0.6448587,0.0003254944,0.007259937,0.0004647104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897729,0.003018948,0.005382677,0.0007659409,0.0004801259,0.000521088,0.00002821533,0.00001298967,0.00001716671],"genre_scores_gemma":[0.9956611,0.001514056,0.001298012,0.001124106,0.0002239532,0.00006474397,0.00005929927,0.00003081987,0.00002391573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.277503,"threshold_uncertainty_score":0.8346538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009677850040674335,"score_gpt":0.2398813149407029,"score_spread":0.2302034649000285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}