{"id":"W3008712021","doi":"10.3389/fphar.2020.00077","title":"Sphingosine-1-Phosphate Receptors Modulators Decrease Signs of Neuroinflammation and Prevent Parkinson’s Disease Symptoms in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model","year":2020,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Neuroinflammation; Parkinson's disease; Sphingosine-1-phosphate receptor; Pharmacology; Receptor; Sphingosine-1-phosphate; Chemistry; Sphingosine; MPTP; Medicine; Disease; Neuroscience; Internal medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000175815,0.0008192933,0.0008247414,0.0006267895,0.0001874119,0.000248693,0.0003194663,0.0006216517,0.001468026],"category_scores_gemma":[0.0001100107,0.0002693317,0.0004235681,0.0001769897,0.0002641348,0.0004627875,0.0001710505,0.001363616,0.0003239837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001851223,"about_ca_system_score_gemma":0.0003516819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005837147,"about_ca_topic_score_gemma":0.001739814,"domain_scores_codex":[0.9998467,0.00001893571,0.00001619255,0.00002873216,0.00004038223,0.00004905235],"domain_scores_gemma":[0.9998782,0.000007760179,0.00004114659,0.00000820778,0.00001797217,0.00004673685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001883736,0.0007791993,0.0001898965,0.0001103007,0.0000233025,0.00006991468,0.00003049896,0.00006094463,0.9930762,0.00006770859,0.0001346863,0.003573673],"study_design_scores_gemma":[0.0005409347,0.01276434,0.007457018,0.00003191811,0.0001414911,0.0002682593,0.00007358476,0.001136736,0.9743063,0.0001307481,0.003132355,0.00001636604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936597,0.003290352,0.001084358,0.0002232725,0.00007306007,0.00007004188,0.000450792,0.0001812787,0.0009672275],"genre_scores_gemma":[0.9828127,0.005139519,0.003554908,0.0001670934,0.00006061589,0.0002593496,0.001086302,0.00004829476,0.006871359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001468026,"threshold_uncertainty_score":0.004911065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009677850040674335,"score_gpt":0.2398813149407029,"score_spread":0.2302034649000285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}