{"id":"W3008712159","doi":"10.1016/j.bone.2020.115287","title":"Favorable skeletal benefit/risk of long-term denosumab therapy: A virtual-twin analysis of fractures prevented relative to skeletal safety events observed","year":2020,"lang":"en","type":"article","venue":"Bone","topic":"Bone health and treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"UCB Pharma; GE Healthcare; Novartis; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Denosumab; Medicine; Osteonecrosis of the jaw; Adverse effect; Placebo; Internal medicine; Osteoporosis; Relative risk; Surgery; Bisphosphonate; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00225945,0.000527057,0.001010715,0.0006880413,0.0006446433,0.00105004,0.0006489549,0.0005830859,0.003985023],"category_scores_gemma":[0.006780529,0.0005025098,0.002428431,0.0006802434,0.0005760001,0.0006350191,0.001437197,0.001161295,0.0002278205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003033324,"about_ca_system_score_gemma":0.0003838015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003772887,"about_ca_topic_score_gemma":0.003858758,"domain_scores_codex":[0.9981681,0.0007555632,0.0001500285,0.0005116761,0.0001491971,0.0002653364],"domain_scores_gemma":[0.9968154,0.001071023,0.0009948435,0.0005301212,0.0001583772,0.0004302744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.03368585,0.0001831914,0.9382389,0.0001407778,0.009290543,0.0004170484,0.0002668148,0.001722427,0.003947899,0.001508152,0.000441828,0.01015651],"study_design_scores_gemma":[0.001036623,0.00496796,0.9475011,0.00008268593,0.01450687,0.003802162,0.001073833,0.01817991,0.001643809,0.005072083,0.001993587,0.0001394655],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966506,0.0006185284,0.001747628,0.00005764827,0.00003103455,0.00001156338,0.0004348958,0.00000812424,0.0004399181],"genre_scores_gemma":[0.9991574,0.00007501126,0.0002675562,0.00002001015,0.000007843705,0.000004771638,0.0002156655,0.000008391298,0.0002433951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003985023,"threshold_uncertainty_score":0.01333123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02912216268467811,"score_gpt":0.305316363084071,"score_spread":0.2761942003993929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}