{"id":"W3008721678","doi":"10.1158/1541-7786.mcr-19-1201","title":"Inactivation of <i>NF1</i> Promotes Resistance to EGFR Inhibition in <i>KRAS/NRAS/BRAFV600</i> -Wild-Type Colorectal Cancer","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Korea National Institute of Health; Imperial Experimental Cancer Medicine Centre; National Institute for Health and Care Research; Institute of Cancer Research; Cancer Research UK; Centro de Investigación Biomédica en Red de Salud Mental; Royal Marsden NHS Foundation Trust","keywords":"KRAS; Neuroblastoma RAS viral oncogene homolog; Colorectal cancer; Cancer research; MEK inhibitor; PTEN; Cetuximab; Cancer; Medicine; Growth inhibition; EGFR inhibitors; MAPK/ERK pathway; Gefitinib; PI3K/AKT/mTOR pathway; Cell growth; Epidermal growth factor receptor; Biology; Internal medicine; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003055363,0.000199547,0.0004618603,0.0002404319,0.0001043761,0.00002428892,0.00009795981,0.00009664511,0.0001275348],"category_scores_gemma":[0.0003426145,0.0001801076,0.0000798597,0.002215427,0.000140084,0.00009659934,0.0001533807,0.0004158042,0.00001192582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009181909,"about_ca_system_score_gemma":0.0005896773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002361582,"about_ca_topic_score_gemma":0.003285508,"domain_scores_codex":[0.9975363,0.0001557143,0.0003500359,0.0005477692,0.0009169392,0.0004932252],"domain_scores_gemma":[0.9987656,0.00006708364,0.00007563951,0.0001910485,0.0006758956,0.0002247409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005215609,0.0002599292,0.01812524,0.0004381804,0.0001534998,0.0002398886,0.002797504,0.0001078298,0.9626757,0.0001654912,0.005072102,0.004749064],"study_design_scores_gemma":[0.002055304,0.001509679,0.02576465,0.000678273,0.00004365728,0.00000239307,0.0003206691,0.00005736693,0.9604413,0.0001233506,0.008801823,0.0002015448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703971,0.004252349,0.0000423706,0.02069132,0.00007950686,0.001507105,0.00004656591,0.00003473163,0.002948909],"genre_scores_gemma":[0.9968433,0.0007465386,0.0001841279,0.001073608,0.0001187112,0.0007374202,0.00002186877,0.00004097452,0.0002334427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02644617,"threshold_uncertainty_score":0.7344575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05739250764713723,"score_gpt":0.3813992004214578,"score_spread":0.3240066927743205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}