{"id":"W3008730699","doi":"10.3390/pharmaceutics12020186","title":"MiR-219a-5p Enriched Extracellular Vesicles Induce OPC Differentiation and EAE Improvement More Efficiently Than Liposomes and Polymeric Nanoparticles","year":2020,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; University of Ottawa","funders":"Agencia Estatal de Investigación; Ikerbasque, Basque Foundation for Science; Instituto de Salud Carlos III; Canadian Institutes of Health Research; European Regional Development Fund; Eusko Jaurlaritza; Deutsche Forschungsgemeinschaft","keywords":"Extracellular vesicles; Liposome; Chemistry; Nanoparticle; Vesicle; Extracellular; Extracellular vesicle; Biophysics; Nanotechnology; Cell biology; Microvesicles; Materials science; Biochemistry; Membrane; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412469,0.0003726159,0.0002590883,0.0002030913,0.0001062454,0.0003359906,0.000113389,0.0002836902,0.0005937048],"category_scores_gemma":[0.0001722321,0.00009845608,0.0002900248,0.00008621941,0.0001801444,0.0003374086,0.0002687792,0.0003558865,0.0002055805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001612371,"about_ca_system_score_gemma":0.0001912988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003205643,"about_ca_topic_score_gemma":0.0004644954,"domain_scores_codex":[0.9998596,0.0000250858,0.00001814303,0.00003428276,0.00003689924,0.00002593545],"domain_scores_gemma":[0.9999284,0.00001335784,0.00002309107,0.000006417701,0.00001600442,0.00001276794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001106754,0.00002739192,0.00006074839,0.00005469026,0.000006249646,0.00003294276,0.00001275659,0.000069284,0.9972571,0.0001093512,0.00003111225,0.002227692],"study_design_scores_gemma":[0.00001211809,0.0002346783,0.0004317684,0.000005771581,0.00002170342,0.00009072913,0.00001191146,0.0005208218,0.9968687,0.00003481084,0.00176326,0.000003707975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837446,0.003574349,0.009869498,0.0001255341,0.00008168106,0.00008012597,0.0002079304,0.0001236699,0.002192533],"genre_scores_gemma":[0.9904498,0.001296225,0.004750114,0.00005156794,0.00001265624,0.00005214576,0.0002075971,0.00003979317,0.003140106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005937048,"threshold_uncertainty_score":0.001986086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02234469320179328,"score_gpt":0.2808602667366106,"score_spread":0.2585155735348173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}