{"id":"W3008730699","doi":"10.3390/pharmaceutics12020186","title":"MiR-219a-5p Enriched Extracellular Vesicles Induce OPC Differentiation and EAE Improvement More Efficiently Than Liposomes and Polymeric Nanoparticles","year":2020,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; University of Ottawa","funders":"Agencia Estatal de Investigación; Ikerbasque, Basque Foundation for Science; Instituto de Salud Carlos III; Canadian Institutes of Health Research; European Regional Development Fund; Eusko Jaurlaritza; Deutsche Forschungsgemeinschaft","keywords":"Extracellular vesicles; Liposome; Chemistry; Nanoparticle; Vesicle; Extracellular; Extracellular vesicle; Biophysics; Nanotechnology; Cell biology; Microvesicles; Materials science; Biochemistry; Membrane; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001230201,0.0002761379,0.0001915188,0.00003717127,0.0001397567,0.00008669177,0.0001864167,0.0001120113,0.00001597661],"category_scores_gemma":[0.00007444657,0.0002782429,0.00006436947,0.0001329246,0.0001812978,0.00001573122,0.0002935876,0.000145452,0.000006012314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001348853,"about_ca_system_score_gemma":0.00003891716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005775522,"about_ca_topic_score_gemma":0.000001420468,"domain_scores_codex":[0.9984868,0.00008362614,0.0003006737,0.0005459519,0.0002215323,0.0003614572],"domain_scores_gemma":[0.9991439,0.00002395426,0.0001360698,0.0002497935,0.0000482098,0.0003980757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001247559,0.0001602057,0.006616777,0.0001163129,0.00008707026,0.00001060015,0.000474175,0.00002351965,0.9809315,0.00005451989,0.00008481032,0.01131574],"study_design_scores_gemma":[0.001236092,0.0002115485,0.007247782,0.000009995386,0.0001548494,0.000007648233,0.0003486855,0.004752218,0.9832711,0.00003580677,0.002394126,0.0003301127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722005,0.02553116,0.0006191368,0.001089188,0.0001046238,0.0003595976,0.00003263362,0.00004229062,0.00002092223],"genre_scores_gemma":[0.9973433,0.0009931379,0.0003913817,0.000844042,0.0001995968,0.00002455919,0.00008336862,0.00004634055,0.00007427964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02514285,"threshold_uncertainty_score":0.999967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02234469320179328,"score_gpt":0.2808602667366106,"score_spread":0.2585155735348173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}