{"id":"W3008749765","doi":"10.1093/jcag/gwz047.005","title":"A6 EFFECTS OF ELUXADOLINE TREATMENT ON ABDOMINAL AND BOWEL SYMPTOMS IN PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH DIARRHEA REPORTING INADEQUATE SYMPTOM CONTROL WITH LOPERAMIDE: AGGREGATED RESULTS FROM PHASE 3 AND 4 CLINICAL TRIALS","year":2020,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; University Health Network; Allergan (Canada)","funders":"","keywords":"Irritable bowel syndrome; Medicine; Loperamide; Tegaserod; Internal medicine; Abdominal pain; Diarrhea; Clinical trial; Placebo; Gastroenterology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00677029,0.0008718171,0.002693421,0.0007124243,0.0003424592,0.001212258,0.0006570763,0.00106622,0.003266718],"category_scores_gemma":[0.006306411,0.00037552,0.005717863,0.0008657417,0.0005788008,0.0009492561,0.0004878157,0.001273169,0.0003031271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006129348,"about_ca_system_score_gemma":0.0008824563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001142635,"about_ca_topic_score_gemma":0.003812724,"domain_scores_codex":[0.9966804,0.002156697,0.0004297964,0.000248655,0.0003146351,0.0001699454],"domain_scores_gemma":[0.9944894,0.002231474,0.002116988,0.0002846382,0.0005091066,0.0003683919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7135994,0.00518785,0.02689192,0.01511313,0.07250462,0.0001677677,0.0002335337,0.002303742,0.007537636,0.0002556737,0.00415442,0.1520502],"study_design_scores_gemma":[0.5190842,0.2442712,0.1621061,0.002361253,0.05757682,0.0003776923,0.0002398156,0.001452161,0.002267356,0.0007490764,0.009381541,0.0001327208],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8595188,0.1261867,0.0008507021,0.001133654,0.0003952525,0.002379708,0.005522339,0.0001250692,0.00388763],"genre_scores_gemma":[0.9753524,0.01780928,0.001138821,0.0008890347,0.0003331292,0.001046535,0.002597875,0.00001324129,0.0008196622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00677029,"threshold_uncertainty_score":0.03580511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861839016033712,"score_gpt":0.2815027911893889,"score_spread":0.2628844010290518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}