{"id":"W3008760290","doi":"10.1111/bcp.14258","title":"Precision therapy of 6‐mercaptopurine in Chinese children with acute lymphoblastic leukaemia","year":2020,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"","keywords":"Leukopenia; Thiopurine methyltransferase; Medicine; Mercaptopurine; Pharmacogenetics; Genotyping; Neutropenia; Internal medicine; Genotype; Gastroenterology; Single-nucleotide polymorphism; Pharmacology; Chemotherapy; Biology; Genetics; Azathioprine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005320191,0.0002759958,0.0003468365,0.0003471033,0.0002822519,0.0003080099,0.0002595903,0.0002052103,0.0005816585],"category_scores_gemma":[0.001012492,0.00009226193,0.000256992,0.0006617851,0.0002166876,0.000144881,0.0002378001,0.0001956779,0.00007107158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007557271,"about_ca_system_score_gemma":0.0007272193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006417212,"about_ca_topic_score_gemma":0.01026816,"domain_scores_codex":[0.9996561,0.00009145893,0.00003858246,0.00006919054,0.0001036465,0.00004094332],"domain_scores_gemma":[0.9996434,0.00007182829,0.000194247,0.00002686683,0.00003153916,0.00003197902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009071757,0.000106631,0.8865268,0.0002835376,0.0002542271,0.001036888,0.000469322,0.001212676,0.02826731,0.000283744,0.0005623655,0.08008938],"study_design_scores_gemma":[0.00008717109,0.001085291,0.9838389,0.00002500599,0.0003448496,0.001725738,0.000198421,0.001763692,0.007681188,0.0002126687,0.003023477,0.0000136913],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963482,0.002287921,0.0004526917,0.0001237898,0.000007670169,0.00002083458,0.0001189012,0.00001762332,0.0006224198],"genre_scores_gemma":[0.9988041,0.0005241187,0.0003573773,0.00005771858,0.000007843541,0.00001379556,0.00008378158,0.000001784962,0.0001494585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006417212,"threshold_uncertainty_score":0.01275975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03480161314211067,"score_gpt":0.3969023865219997,"score_spread":0.3621007733798891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}