{"id":"W3008788284","doi":"10.1101/2020.02.25.965194","title":"LRRK2 mutation alters behavioral, synaptic and non-synaptic adaptations to acute social stress","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Mental Health","keywords":"Synaptic plasticity; Nucleus accumbens; Neuroscience; Medium spiny neuron; LRRK2; Synaptic fatigue; Biology; Mutation; Psychology; Gene; Genetics; Basal ganglia; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008502831,0.000420263,0.0002686552,0.000270198,0.0001476079,0.0002169708,0.0001626416,0.0004534542,0.003017822],"category_scores_gemma":[0.0001096401,0.0001144068,0.0003472688,0.0001451628,0.0003351277,0.0001481851,0.0002442149,0.0005404769,0.0005233029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002337187,"about_ca_system_score_gemma":0.0001043808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007792531,"about_ca_topic_score_gemma":0.0009373418,"domain_scores_codex":[0.9998947,0.00001471717,0.00001542296,0.00003146356,0.00002164681,0.00002196678],"domain_scores_gemma":[0.9998894,0.00001216733,0.00004264131,0.00001025806,0.000005926789,0.00003954135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005222948,0.00007021938,0.001010822,0.00002793227,0.00002024867,0.0004691374,0.00002221933,0.0000720008,0.9963631,0.00007406883,0.0001790661,0.00116898],"study_design_scores_gemma":[0.000132687,0.001505338,0.1147718,0.00004932773,0.0001192219,0.006839435,0.0002557724,0.002554625,0.8689233,0.0005342817,0.004276749,0.0000375076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970295,0.0002408536,0.0006412239,0.0001357801,0.00004181156,0.000009594506,0.001000247,0.0001073554,0.0007935351],"genre_scores_gemma":[0.9966365,0.0001911423,0.0004261918,0.00008645657,0.00001056684,0.00002098892,0.0005278628,0.00005602589,0.002044241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003017822,"threshold_uncertainty_score":0.0100956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05798368061847286,"score_gpt":0.3227180191540269,"score_spread":0.264734338535554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}