{"id":"W3008870054","doi":"10.3390/biom10020334","title":"Anti-Infectives Restore ORKAMBI® Rescue of F508del-CFTR Function in Human Bronchial Epithelial Cells Infected with Clinical Strains of P. aeruginosa","year":2020,"lang":"en","type":"article","venue":"Biomolecules","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Canadian Institutes of Health Research; Cystic Fibrosis Foundation Therapeutics","keywords":"Cystic fibrosis; Pseudomonas aeruginosa; Tobramycin; Cystic fibrosis transmembrane conductance regulator; Ivacaftor; Medicine; Microbiology; Sputum; Lung; Immunology; Cancer research; Biology; Internal medicine; Pathology; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002867409,0.0001979697,0.0006431147,0.0002061978,0.00003739548,0.00001031456,0.0001299773,0.0001373007,0.00006283516],"category_scores_gemma":[0.000608618,0.0001586588,0.0001386909,0.0006238703,0.0007794846,0.00008865363,0.0000794157,0.0003179238,0.000006592049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004081042,"about_ca_system_score_gemma":0.0002747333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004033004,"about_ca_topic_score_gemma":0.0003739904,"domain_scores_codex":[0.9978498,0.0002446489,0.000675226,0.0004226256,0.00050481,0.0003029403],"domain_scores_gemma":[0.9989231,0.0001522975,0.0001988651,0.0002971376,0.0002155652,0.0002130301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001821925,0.0005079831,0.07992743,0.0003163186,0.0001005066,0.00006156554,0.0002021204,0.00006434644,0.9138561,0.0003323463,0.0001553744,0.002654002],"study_design_scores_gemma":[0.003931666,0.005503022,0.640942,0.0002785312,0.00007107633,0.000006508721,0.0001738043,0.0001675657,0.3482126,0.00004551063,0.0005150898,0.0001525935],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965206,0.0001837594,0.001882901,0.000314032,0.00008170029,0.0005747036,0.00009541213,0.00005029082,0.0002965893],"genre_scores_gemma":[0.9980612,0.00005281347,0.001525122,0.00005787773,0.0001963497,0.000009949657,0.00005284264,0.00003000054,0.00001382338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5656435,"threshold_uncertainty_score":0.6469916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03084239648031371,"score_gpt":0.337535791103194,"score_spread":0.3066933946228803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}