{"id":"W3008870054","doi":"10.3390/biom10020334","title":"Anti-Infectives Restore ORKAMBI® Rescue of F508del-CFTR Function in Human Bronchial Epithelial Cells Infected with Clinical Strains of P. aeruginosa","year":2020,"lang":"en","type":"article","venue":"Biomolecules","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Canadian Institutes of Health Research; Cystic Fibrosis Foundation Therapeutics","keywords":"Cystic fibrosis; Pseudomonas aeruginosa; Tobramycin; Cystic fibrosis transmembrane conductance regulator; Ivacaftor; Medicine; Microbiology; Sputum; Lung; Immunology; Cancer research; Biology; Internal medicine; Pathology; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001226438,0.0002993066,0.0004652149,0.0001687987,0.000118409,0.0002412772,0.0002034425,0.0002592939,0.001113071],"category_scores_gemma":[0.00009804488,0.000117331,0.0003427572,0.0001262604,0.0001292698,0.000109941,0.0001844867,0.0005765249,0.0004989298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001094048,"about_ca_system_score_gemma":0.0001894741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005231702,"about_ca_topic_score_gemma":0.0005797841,"domain_scores_codex":[0.9998335,0.00002975088,0.00001788763,0.00001843562,0.00005628306,0.00004412946],"domain_scores_gemma":[0.9999261,0.00001409389,0.0000197226,0.00001220712,0.00001134482,0.00001662134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001424003,0.00006948839,0.000127449,0.00005419823,0.000004409289,0.00004367366,0.0000153391,0.0000283664,0.9983948,0.00002002705,0.00004335089,0.001056556],"study_design_scores_gemma":[0.00004410655,0.001582966,0.006263916,0.00001618011,0.00001975261,0.0003589661,0.00005089489,0.0003998763,0.9879472,0.00001623479,0.003294721,0.000005150565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958997,0.002193657,0.000618574,0.00008978405,0.0000454431,0.00002892363,0.0003287044,0.00004215661,0.0007530529],"genre_scores_gemma":[0.9922775,0.002129785,0.001796396,0.00009656339,0.00002194438,0.00005114674,0.001147287,0.00002185414,0.002457472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113071,"threshold_uncertainty_score":0.003723562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03084239648031371,"score_gpt":0.337535791103194,"score_spread":0.3066933946228803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}