{"id":"W3008877371","doi":"10.1016/j.dld.2019.12.123","title":"Overall Health, Daily Functioning, and Quality of Life in Acute Hepatic Porphyria Patients: ENVISION, a Phase 3 Global, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial","year":2020,"lang":"en","type":"article","venue":"Digestive and Liver Disease","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton","funders":"","keywords":"Medicine; Porphyria; Quality of life (healthcare); Porphobilinogen synthase; Placebo; Heme; Disease; Randomized controlled trial; Liver enzyme; Internal medicine; Enzyme; Dehydratase; Pathology; Biochemistry; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003535457,0.0002305441,0.0007538152,0.00003747141,0.00007444619,0.00003058409,0.00008756248,0.00007420225,0.00001881607],"category_scores_gemma":[0.0006865189,0.0001945696,0.0001800332,0.00007911108,0.0001811991,0.00002291586,0.0001030618,0.00007325863,0.000001870936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009360954,"about_ca_system_score_gemma":0.0001800445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004677854,"about_ca_topic_score_gemma":0.00003401275,"domain_scores_codex":[0.9980741,0.0004387375,0.0006150429,0.0004639734,0.0001861726,0.0002219693],"domain_scores_gemma":[0.9988061,0.00007318197,0.0003506584,0.0001645782,0.00008967538,0.000515851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9538082,0.0008972173,0.04375089,0.00008707748,0.0002286212,0.000002685022,0.0002216314,0.00001330452,0.0001156624,0.000145287,0.0002398806,0.0004894719],"study_design_scores_gemma":[0.9670181,0.0005583741,0.03132745,0.00002174328,0.0002005137,9.264721e-8,0.00006090588,0.0003068021,0.00001860027,0.00003874183,0.0002534391,0.000195244],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874583,0.00860711,0.0003970679,0.0003188972,0.000105459,0.002771341,0.0002654957,0.00000870607,0.00006765203],"genre_scores_gemma":[0.9949675,0.002692747,0.00005540077,0.001601306,0.00008113198,0.0001830976,0.0003863236,0.00001070756,0.0000217476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01320983,"threshold_uncertainty_score":0.7934318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02080360361688649,"score_gpt":0.300469278669233,"score_spread":0.2796656750523465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}