{"id":"W3008877371","doi":"10.1016/j.dld.2019.12.123","title":"Overall Health, Daily Functioning, and Quality of Life in Acute Hepatic Porphyria Patients: ENVISION, a Phase 3 Global, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial","year":2020,"lang":"en","type":"article","venue":"Digestive and Liver Disease","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton","funders":"","keywords":"Medicine; Porphyria; Quality of life (healthcare); Porphobilinogen synthase; Placebo; Heme; Disease; Randomized controlled trial; Liver enzyme; Internal medicine; Enzyme; Dehydratase; Pathology; Biochemistry; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001328026,0.001852214,0.003042028,0.0004056585,0.000469884,0.000984808,0.0007610886,0.001548519,0.003419144],"category_scores_gemma":[0.001140797,0.0004951476,0.001899146,0.0003478644,0.001169877,0.0008836847,0.0005175953,0.002465281,0.0004599982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005517745,"about_ca_system_score_gemma":0.0007811182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008905911,"about_ca_topic_score_gemma":0.001385634,"domain_scores_codex":[0.999642,0.0001798993,0.00002041961,0.00006744154,0.00002545815,0.00006470911],"domain_scores_gemma":[0.9993514,0.0001912839,0.0001687883,0.00004003358,0.00003346242,0.0002149728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9760275,0.004399436,0.001799461,0.0004970995,0.001013353,0.00003502427,0.00004673986,0.000409879,0.002121824,0.00009304618,0.0006222836,0.01293437],"study_design_scores_gemma":[0.9499036,0.04377344,0.00451324,0.0000400936,0.000568326,0.0000381429,0.00003310738,0.0003967004,0.0002609736,0.000150618,0.0003055385,0.00001623795],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912485,0.005086765,0.0004700147,0.0005192626,0.0001482698,0.0008903182,0.0006392773,0.00009703169,0.0009004763],"genre_scores_gemma":[0.9914051,0.002622239,0.001262442,0.0008585129,0.0002550753,0.001753264,0.0008598407,0.00001558827,0.0009679493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003419144,"threshold_uncertainty_score":0.01143813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02080360361688649,"score_gpt":0.300469278669233,"score_spread":0.2796656750523465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}