{"id":"W3008881558","doi":"10.1038/s42003-020-0808-5","title":"Investigating cone photoreceptor development using patient-derived NRL null retinal organoids","year":2020,"lang":"en","type":"article","venue":"Communications Biology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Eye Institute; National Institutes of Health; Retina Research Foundation; University of Wisconsin-Madison; Waisman Center; Maryland Stem Cell Research Fund; Foundation Fighting Blindness; Johns Hopkins University; Research to Prevent Blindness","keywords":"Biology; Retinal degeneration; Retinitis pigmentosa; Retinal regeneration; Opsin; Retina; Retinal; Cell biology; Photoreceptor cell; Organoid; Neuroscience; Genetics; Rhodopsin; Botany","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005457212,0.000466023,0.0003626739,0.0005497641,0.000306373,0.0004751094,0.0002860408,0.0005874346,0.002839981],"category_scores_gemma":[0.0002880221,0.0002001046,0.0004821529,0.000235467,0.0003903643,0.000213397,0.0002810396,0.0008688672,0.0009248983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004090852,"about_ca_system_score_gemma":0.0002744248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006838262,"about_ca_topic_score_gemma":0.001277737,"domain_scores_codex":[0.9996469,0.00005036337,0.00005424359,0.0001090979,0.0001045142,0.00003489175],"domain_scores_gemma":[0.9997192,0.00008224342,0.00004418577,0.00006977958,0.00002601469,0.00005854512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004429651,0.00003895681,0.0003374106,0.00002101144,0.000007190853,0.0002491357,0.00005651321,0.0001016639,0.9980643,0.0001761082,0.00004850774,0.0008548647],"study_design_scores_gemma":[0.00003398499,0.0005138617,0.003667013,0.00001275678,0.00004153548,0.002941711,0.0001098523,0.00142493,0.9858974,0.0001171032,0.005227509,0.00001237672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9653538,0.001026556,0.02385988,0.0002271126,0.00009532101,0.0004489056,0.003657509,0.0004189068,0.004912047],"genre_scores_gemma":[0.9764037,0.0009093086,0.01439082,0.0001263237,0.000009838733,0.0002936982,0.002612493,0.0001074394,0.005146399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002839981,"threshold_uncertainty_score":0.009500682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05163612814517458,"score_gpt":0.2855395138801106,"score_spread":0.233903385734936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}