{"id":"W3008881558","doi":"10.1038/s42003-020-0808-5","title":"Investigating cone photoreceptor development using patient-derived NRL null retinal organoids","year":2020,"lang":"en","type":"article","venue":"Communications Biology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Eye Institute; National Institutes of Health; Retina Research Foundation; University of Wisconsin-Madison; Waisman Center; Maryland Stem Cell Research Fund; Foundation Fighting Blindness; Johns Hopkins University; Research to Prevent Blindness","keywords":"Biology; Retinal degeneration; Retinitis pigmentosa; Retinal regeneration; Opsin; Retina; Retinal; Cell biology; Photoreceptor cell; Organoid; Neuroscience; Genetics; Rhodopsin; Botany","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001044928,0.0001679768,0.0001623104,0.00003356944,0.0003012336,0.00001908829,0.0006129675,0.0001548382,0.00005923385],"category_scores_gemma":[0.0003158153,0.000169762,0.00004528276,0.0001685646,0.0003369515,0.000004685796,0.0007204601,0.0001439367,0.00004421606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002343563,"about_ca_system_score_gemma":0.0002520216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001196243,"about_ca_topic_score_gemma":0.00001444083,"domain_scores_codex":[0.9988824,0.0001767345,0.000347343,0.0002970587,0.00005987506,0.0002366438],"domain_scores_gemma":[0.9990189,0.00002728457,0.0001540927,0.0005384676,0.0001281136,0.0001331066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001486021,0.00003256053,0.01996189,0.000009245208,0.0000403117,1.705767e-7,0.0007531171,0.000003861006,0.975057,0.0001195108,0.0007341381,0.003273345],"study_design_scores_gemma":[0.0007691588,0.0003337564,0.002564766,0.00002962879,0.00002283135,0.00001053533,0.001096932,0.0006250957,0.6878929,0.0001124906,0.3059725,0.0005693993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934896,0.001150999,0.001849653,0.001346978,0.00007027339,0.0002165684,0.000009218807,0.00003502859,0.001831639],"genre_scores_gemma":[0.9412479,0.0002091506,0.05599127,0.001656927,0.00004617771,0.00003325522,0.0007737695,0.00002012317,0.00002137219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3052384,"threshold_uncertainty_score":0.6922693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05163612814517458,"score_gpt":0.2855395138801106,"score_spread":0.233903385734936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}