{"id":"W3008901859","doi":"10.1002/cpdd.773","title":"Absolute Bioavailability of Vemurafenib in Patients With <i>BRAF</i><sup>V600</sup> Mutation–Positive Malignancies","year":2020,"lang":"en","type":"article","venue":"Clinical Pharmacology in Drug Development","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Vemurafenib; Medicine; Bioavailability; Mutation; Internal medicine; Cancer research; Oncology; Pharmacology; Cancer; Genetics; Metastatic melanoma; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004212505,0.0002836412,0.0007420141,0.000146304,0.000213611,0.0003299957,0.0001261436,0.0002934747,0.0007953274],"category_scores_gemma":[0.0007670475,0.0001996615,0.0002823526,0.0000909779,0.0001526916,0.0003532367,0.0001463876,0.0005784933,0.0001879411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003006304,"about_ca_system_score_gemma":0.0002452256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004366798,"about_ca_topic_score_gemma":0.0003909988,"domain_scores_codex":[0.9998367,0.00005827452,0.00001002276,0.0000427955,0.00002647464,0.0000256926],"domain_scores_gemma":[0.999686,0.00009615094,0.0001083051,0.00001643183,0.00002514465,0.00006794431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1602334,0.005074006,0.3611588,0.0002784719,0.0006235663,0.001316688,0.0005076496,0.004577148,0.3502855,0.0001996797,0.00186648,0.1138786],"study_design_scores_gemma":[0.01056561,0.1758416,0.7305996,0.00003345158,0.0007995759,0.003811913,0.0002529428,0.01251976,0.06034199,0.000294458,0.004856795,0.00008227774],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990934,0.0003550355,0.0002410755,0.00002626155,0.000004020368,0.00002316339,0.00005693867,0.00001532747,0.0001847854],"genre_scores_gemma":[0.9994041,0.00007420687,0.0001818408,0.00004147214,0.00001001628,0.00001893058,0.000118061,0.000003434974,0.0001479416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007953274,"threshold_uncertainty_score":0.002660632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01810976022212002,"score_gpt":0.2810174184975781,"score_spread":0.262907658275458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}