{"id":"W3008934877","doi":"10.1016/j.bmcl.2020.127067","title":"Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents","year":2020,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Crohn's and Colitis Canada; Università degli Studi di Ferrara; Associazione Italiana per la Ricerca sul Cancro; Università degli Studi di Firenze; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Chemistry; Adenosine; Adenosine receptor; Pyrimidine; Stereochemistry; Receptor; Enzyme; G protein-coupled receptor; Potency; Adenosine A2A receptor; Pharmacology; Biochemistry; Combinatorial chemistry; In vitro; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001255132,0.0002106433,0.0002103732,0.000115828,0.0002103012,0.0001828838,0.0002956573,0.0002306175,0.002398599],"category_scores_gemma":[0.0001007665,0.00009935395,0.0001468373,0.0001227508,0.0001583692,0.0001664659,0.0001286334,0.0003550657,0.0002992512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002770535,"about_ca_system_score_gemma":0.0003774308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001063249,"about_ca_topic_score_gemma":0.0021657,"domain_scores_codex":[0.9999564,0.000007647355,0.00000275741,0.000006711477,0.00001144995,0.00001514343],"domain_scores_gemma":[0.9999698,0.000004889465,0.000007951537,0.000002593711,0.000004735075,0.000009972986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003774933,0.0001302385,0.0001884897,0.0002066827,0.00001646196,0.000505518,0.00005452583,0.002116636,0.9827305,0.002649245,0.000360772,0.01066344],"study_design_scores_gemma":[0.000535659,0.005379601,0.00349496,0.00006423445,0.0001181269,0.001542105,0.0001121737,0.00953267,0.9454552,0.0007637214,0.03295275,0.00004870923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825533,0.005523702,0.004245338,0.0003881958,0.00007683678,0.00009635709,0.0002689192,0.00007785477,0.006769328],"genre_scores_gemma":[0.9889042,0.004106431,0.003929245,0.0001250302,0.00001712777,0.00003057708,0.0002461047,0.000007293845,0.002634101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002398599,"threshold_uncertainty_score":0.008024156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02091210705638539,"score_gpt":0.2384298850291678,"score_spread":0.2175177779727824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}