{"id":"W3008959887","doi":"10.1096/fj.201902649r","title":"Substrate‐selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains","year":2020,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Ectodomain; Disintegrin; Metalloproteinase; Epidermal growth factor; Cell biology; Transmembrane domain; Epidermal growth factor receptor; Mutant; Transmembrane protein; Biology; Chemistry; Receptor; Biochemistry; Matrix metalloproteinase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445464,0.0003191905,0.0002372579,0.0001578659,0.0001410854,0.0003337347,0.0002674334,0.0002385722,0.001391473],"category_scores_gemma":[0.0001471579,0.0001597167,0.0002854311,0.0001037083,0.00023795,0.0001556801,0.000313357,0.000566759,0.0006214568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001878241,"about_ca_system_score_gemma":0.0001012117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001802436,"about_ca_topic_score_gemma":0.0001908696,"domain_scores_codex":[0.9998331,0.00002821022,0.00002448383,0.0000303033,0.00004507253,0.00003884169],"domain_scores_gemma":[0.9997959,0.00002768675,0.00007561507,0.00002982148,0.00001237977,0.00005868657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001014313,0.00001435965,0.0006315592,0.00001116121,0.000004056958,0.0001953973,0.000008847498,0.00002876728,0.9985879,0.00007818213,0.00002576701,0.0003126176],"study_design_scores_gemma":[0.00003354025,0.0001224576,0.01839903,0.000005144378,0.0000193954,0.003001378,0.00005816109,0.001146652,0.9747121,0.00006939866,0.002426006,0.000006721459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982448,0.0002788915,0.0008162273,0.00003484899,0.00001320923,0.00000504166,0.0001144759,0.0000212035,0.0004714002],"genre_scores_gemma":[0.9973424,0.0001389768,0.0006987245,0.00003096796,0.00001020096,0.00001404614,0.0003745664,0.00002394918,0.001366242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001391473,"threshold_uncertainty_score":0.004654944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02944893584627624,"score_gpt":0.2900757147255682,"score_spread":0.260626778879292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}