{"id":"W3008969995","doi":"10.1128/aac.02101-19","title":"Discordance between Etravirine Phenotype and Genotype-Based Predicted Phenotype for Subtype C HIV-1 from First-Line Antiretroviral Therapy Failures in South Africa","year":2020,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; University of British Columbia","funders":"Canadian Institutes of Health Research; U.S. President’s Emergency Plan for AIDS Relief; Bill and Melinda Gates Foundation; United States Agency for International Development","keywords":"Etravirine; Genotype; Phenotype; Virology; Human immunodeficiency virus (HIV); Antiretroviral therapy; Biology; Genetics; Medicine; Viral load; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001707022,0.0002311745,0.0002207219,0.001094827,0.0003608094,0.0008253087,0.0003394697,0.0004044813,0.001159213],"category_scores_gemma":[0.007636817,0.000208684,0.0001730474,0.0005716942,0.000488888,0.0003358531,0.0003503335,0.0003712157,0.0001681309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005309458,"about_ca_system_score_gemma":0.0002911832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01140259,"about_ca_topic_score_gemma":0.01233962,"domain_scores_codex":[0.999145,0.0003733231,0.0001016367,0.0001374022,0.0001494108,0.00009328849],"domain_scores_gemma":[0.9983582,0.0008640109,0.0004073456,0.000139826,0.0001482151,0.00008245534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002664014,0.00001405002,0.9927078,0.00001741043,0.00002202375,0.000246436,0.0004083773,0.0002364484,0.001697369,0.00003730956,0.0001228954,0.004223557],"study_design_scores_gemma":[0.00001446976,0.00008765606,0.9930329,0.00003770968,0.00002011432,0.001770703,0.0006779277,0.002475023,0.001435726,0.00007918469,0.0003612375,0.000007269067],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992667,0.0000974173,0.0001177976,0.0000286458,0.000003585305,0.000007163122,0.0001257595,0.000004442906,0.0003484526],"genre_scores_gemma":[0.999715,0.00002467888,0.000122235,0.00001222996,0.000001608053,0.000002680693,0.00006870527,0.000001709598,0.00005113509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01140259,"threshold_uncertainty_score":0.02267241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02840333149656863,"score_gpt":0.2479251438544464,"score_spread":0.2195218123578778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}