{"id":"W3009067006","doi":"10.1186/s13073-020-0716-9","title":"Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age","year":2020,"lang":"en","type":"review","venue":"Genome Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Medical Research Council; Wellcome Trust; Biotechnology and Biological Sciences Research Council; Uppsala Universitet; World Health Organization","keywords":"Epigenome; DNA methylation; Meta-analysis; Human genetics; Computational biology; Biology; Gestational age; Genetics; Bioinformatics; Medicine; Pregnancy; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007719022,0.0004092882,0.002586859,0.0007245051,0.0000440183,0.00001551877,0.0002485383,0.0003217061,0.0001321789],"category_scores_gemma":[0.0003580336,0.0003324151,0.0006240691,0.001306911,0.0001064837,0.000004285105,0.0001455728,0.0001945486,0.000006165768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002288903,"about_ca_system_score_gemma":0.0001002965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001088846,"about_ca_topic_score_gemma":0.0001237581,"domain_scores_codex":[0.9971471,0.0003187698,0.001241067,0.0007338811,0.0003262947,0.0002328442],"domain_scores_gemma":[0.998587,0.0001235137,0.0005710477,0.0004498575,0.00009911288,0.0001695153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0001036646,0.0004377483,0.003648594,0.005864426,0.5764799,0.0001623618,0.004449449,0.002490125,0.04990992,0.0004725052,0.0001482807,0.3558331],"study_design_scores_gemma":[0.0009509062,0.0007945633,0.02355926,0.0002104919,0.4924499,0.000005738436,0.00006344389,0.000007532845,0.0006002254,0.0004986094,0.4798711,0.0009882435],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009941736,0.9879431,0.0006670394,0.0002420662,0.00004375726,0.000784828,0.0002193204,0.000007730793,0.0001504046],"genre_scores_gemma":[0.01046218,0.9812205,0.0005685755,0.00007095448,0.0001019892,0.00006874933,0.007116112,0.0000508292,0.0003400687],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4797228,"threshold_uncertainty_score":0.9999128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04232468330241483,"score_gpt":0.3246173906453712,"score_spread":0.2822927073429564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}