{"id":"W3009067006","doi":"10.1186/s13073-020-0716-9","title":"Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age","year":2020,"lang":"en","type":"review","venue":"Genome Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Medical Research Council; Wellcome Trust; Biotechnology and Biological Sciences Research Council; Uppsala Universitet; World Health Organization","keywords":"Epigenome; DNA methylation; Meta-analysis; Human genetics; Computational biology; Biology; Gestational age; Genetics; Bioinformatics; Medicine; Pregnancy; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005069639,0.001124605,0.002677796,0.002575145,0.0006191786,0.001509956,0.00113531,0.001001907,0.002093822],"category_scores_gemma":[0.01031947,0.0006412428,0.0104396,0.004656955,0.0004616417,0.0005799828,0.001328207,0.0012718,0.0001978751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006253956,"about_ca_system_score_gemma":0.0008575423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01136887,"about_ca_topic_score_gemma":0.01407516,"domain_scores_codex":[0.9960868,0.001547844,0.0003293018,0.00142138,0.0003625205,0.0002521406],"domain_scores_gemma":[0.9943011,0.003275623,0.0007858415,0.001117628,0.0002945806,0.0002252441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00226973,0.00002866524,0.7492093,0.003261825,0.2119615,0.0003491276,0.0002064612,0.003360361,0.005302227,0.0005468756,0.002165454,0.0213384],"study_design_scores_gemma":[0.0001547147,0.0002690493,0.8453752,0.0007423868,0.1394689,0.0005235357,0.0001901863,0.003775059,0.002097892,0.001521837,0.005832659,0.00004861794],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7201896,0.2302661,0.021569,0.002433382,0.000392443,0.0001012358,0.02210041,0.0006188633,0.002328944],"genre_scores_gemma":[0.9775156,0.01424311,0.003358288,0.0004009174,0.0000898056,0.00009035532,0.00383236,0.0001029627,0.0003665038],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01136887,"threshold_uncertainty_score":0.02681118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04232468330241483,"score_gpt":0.3246173906453712,"score_spread":0.2822927073429564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}