{"id":"W3009078156","doi":"10.1073/pnas.1916965117","title":"Intestinal bile acids directly modulate the structure and function of <i>C. difficile</i> TcdB toxin","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Government of Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Bile acid; Toxin; Oligopeptide; Clostridium difficile toxin A; Chemistry; Amino acid; Receptor; Biochemistry; Biology; Peptide; Clostridium difficile","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004921413,0.00009854831,0.0001984061,0.00008089981,0.0001388592,0.00001631209,0.0003592266,0.0000693607,0.00003220515],"category_scores_gemma":[0.001022289,0.00005210803,0.00007336128,0.0009070528,0.000939332,0.0001234668,0.0001760999,0.0002871038,5.420252e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002175337,"about_ca_system_score_gemma":0.00006179454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007871207,"about_ca_topic_score_gemma":6.134941e-8,"domain_scores_codex":[0.9981179,0.000008069381,0.0002999666,0.0002289061,0.001202269,0.0001428848],"domain_scores_gemma":[0.9991874,0.0001434683,0.0002413876,0.0000120915,0.0003518276,0.00006386788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001441596,0.0000326435,0.006101205,0.0001550492,0.00002184695,1.334814e-8,0.0001980988,0.00004808346,0.9889935,0.002259246,0.0006229613,0.001423239],"study_design_scores_gemma":[0.0003095107,0.0003356167,0.04550807,0.0001081686,0.00004227131,0.00001582503,0.0002535074,0.002831033,0.948377,0.001931541,0.0002337773,0.00005372081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860078,0.0002744032,0.000001213247,0.01208422,0.00001259232,0.000228151,0.00002755375,0.00001030984,0.001353786],"genre_scores_gemma":[0.9991756,0.00005149273,0.000181836,0.0003894874,0.0001309019,0.000002955528,3.209605e-7,0.000004811243,0.00006258522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0406165,"threshold_uncertainty_score":0.3461008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04356594761244128,"score_gpt":0.3003552676207411,"score_spread":0.2567893200082998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}