{"id":"W3009135015","doi":"10.1158/1535-7163.targ-19-b001","title":"Abstract B001: Safety and efficacy of ZW25, a HER2-targeted bispecific antibody, in combination with chemotherapy in patients with locally advanced and/or metastatic HER2-expressing gastroesophageal cancer","year":2019,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Capecitabine; Medicine; Trastuzumab; Internal medicine; Oncology; Cancer; Chemotherapy; Response Evaluation Criteria in Solid Tumors; Metastatic breast cancer; Paclitaxel; Breast cancer; Phases of clinical research; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002572091,0.0003261142,0.00066106,0.0002680604,0.0000353385,0.00003264003,0.0001294837,0.00009280492,0.0001373157],"category_scores_gemma":[0.000009897345,0.0002425915,0.00003667815,0.0006208411,0.0002285517,0.0001252719,0.00003397213,0.0004278423,9.00432e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003443684,"about_ca_system_score_gemma":0.0004664216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005420914,"about_ca_topic_score_gemma":0.0004076709,"domain_scores_codex":[0.9976878,0.0001109372,0.0004686277,0.0005326726,0.0007092665,0.0004906807],"domain_scores_gemma":[0.9989749,0.00008524063,0.0002130329,0.0003719539,0.0002293824,0.0001254974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02440039,0.001124229,0.7975185,0.000893218,0.000373813,0.0001196158,0.001312747,0.002196484,0.05361681,0.00002095199,0.000001961907,0.1184213],"study_design_scores_gemma":[0.03141141,0.002175437,0.9472937,0.002064629,0.00007695855,0.000005086585,0.0001597109,0.001061899,0.01510123,0.00001303293,0.0003552705,0.0002816597],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935234,0.003302281,0.000578951,0.0005156351,0.0000451236,0.00191361,0.00003214387,0.00002129929,0.00006755337],"genre_scores_gemma":[0.9957237,0.001778103,0.001780525,0.0004597825,0.00001117053,0.00006936525,0.00003818001,0.00009689031,0.00004234272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1497752,"threshold_uncertainty_score":0.9892594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167205724280495,"score_gpt":0.3281169170133715,"score_spread":0.3113963445853219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}