{"id":"W3009135015","doi":"10.1158/1535-7163.targ-19-b001","title":"Abstract B001: Safety and efficacy of ZW25, a HER2-targeted bispecific antibody, in combination with chemotherapy in patients with locally advanced and/or metastatic HER2-expressing gastroesophageal cancer","year":2019,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Capecitabine; Medicine; Trastuzumab; Internal medicine; Oncology; Cancer; Chemotherapy; Response Evaluation Criteria in Solid Tumors; Metastatic breast cancer; Paclitaxel; Breast cancer; Phases of clinical research; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003948518,0.0005018914,0.0006261417,0.0002645542,0.0001492472,0.0003753577,0.0003114265,0.0003452548,0.002863338],"category_scores_gemma":[0.0005260775,0.0001758837,0.0004338133,0.000202424,0.0002515585,0.0003782394,0.0002045143,0.0009513507,0.0005465228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004800194,"about_ca_system_score_gemma":0.000552167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005651647,"about_ca_topic_score_gemma":0.001559171,"domain_scores_codex":[0.9998702,0.00005498234,0.00001196725,0.00002301629,0.00002070207,0.00001919759],"domain_scores_gemma":[0.9998461,0.0000292459,0.00003749758,0.00001016788,0.00001145779,0.00006544356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3364495,0.01545063,0.01638732,0.001274357,0.001489867,0.0007034811,0.0002753226,0.003186382,0.1617514,0.0003559015,0.006485399,0.4561905],"study_design_scores_gemma":[0.1955151,0.6337738,0.09171682,0.0001751004,0.001877928,0.001953932,0.0001571714,0.005778693,0.052056,0.0002868921,0.01664772,0.00006091095],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935343,0.002910911,0.0004185644,0.0001912459,0.00004009183,0.0003349259,0.0004554365,0.00006976486,0.002044723],"genre_scores_gemma":[0.995784,0.001200926,0.0005054859,0.0001730876,0.00004245255,0.0001785717,0.0008819014,0.00001215374,0.001221311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002863338,"threshold_uncertainty_score":0.009578824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167205724280495,"score_gpt":0.3281169170133715,"score_spread":0.3113963445853219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}