{"id":"W3009177262","doi":"10.1136/bmjdrc-2019-001025","title":"Glucagon receptor antagonist upregulates circulating GLP-1 level by promoting intestinal L-cell proliferation and GLP-1 production in type 2 diabetes","year":2020,"lang":"en","type":"article","venue":"BMJ Open Diabetes Research & Care","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"General Hospital of People’s Liberation Army; National Key Research and Development Program of China; Peking University Third Hospital; Peking University; University of Toronto; National Natural Science Foundation of China; Sun Yat-sen University; Tsinghua University","keywords":"Glucagon receptor; Internal medicine; Endocrinology; Receptor; Glucagon-like peptide 1 receptor; Streptozotocin; Glucagon-like peptide-1; Glucagon; Cell growth; Diabetes mellitus; Receptor antagonist; Antagonist; Type 2 diabetes; Medicine; Biology; Insulin; Agonist; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001161698,0.0003618342,0.0003274391,0.0001936687,0.00009785304,0.0002022756,0.0001378904,0.0002524174,0.002245216],"category_scores_gemma":[0.00008045903,0.0001165588,0.0002935376,0.0001157073,0.0001479025,0.0001448773,0.000105211,0.0006920653,0.0003753302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001421282,"about_ca_system_score_gemma":0.0001477657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001606971,"about_ca_topic_score_gemma":0.0003689596,"domain_scores_codex":[0.9999297,0.00001517902,0.000006533523,0.00001158088,0.00001755591,0.00001944002],"domain_scores_gemma":[0.9999632,0.000004334434,0.000008972414,0.000003221194,0.000003390857,0.00001705784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001708872,0.0002843418,0.0005475632,0.0001589607,0.00001791934,0.0001428997,0.0000124496,0.00005679412,0.9924976,0.00004140526,0.0002079395,0.004323331],"study_design_scores_gemma":[0.001769888,0.01663491,0.0376711,0.00006368706,0.0002533677,0.001580369,0.0001443395,0.001298198,0.9283043,0.0001102401,0.01214523,0.00002423153],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990925,0.00465631,0.001511207,0.0001920029,0.0001346505,0.00005099608,0.0002469581,0.0001274948,0.002155385],"genre_scores_gemma":[0.9883604,0.004117208,0.002600788,0.0003821978,0.000108031,0.0001672173,0.0006452049,0.00003069322,0.003588251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002245216,"threshold_uncertainty_score":0.00751102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1053879091548458,"score_gpt":0.3843523455843713,"score_spread":0.2789644364295256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}