{"id":"W3009228664","doi":"10.1002/bdr2.1666","title":"Gestational exposure to valproic acid upregulates total Stat3 protein expression while downregulating phosphorylated Stat3 in CD‐1 mouse embryos with neural tube defects","year":2020,"lang":"en","type":"article","venue":"Birth Defects Research","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Neural tube; STAT3; Embryo; Downregulation and upregulation; STAT protein; Biology; Phosphorylation; Valproic Acid; Andrology; Endocrinology; Embryogenesis; In utero; Internal medicine; Fetus; Medicine; Pregnancy; Cell biology; Biochemistry; Genetics; Epilepsy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001013346,0.0004167897,0.0005443367,0.0003766209,0.0004430092,0.0001120622,0.0004178004,0.000294648,0.0004731053],"category_scores_gemma":[0.000715615,0.0003322639,0.000099288,0.001305729,0.0002410493,0.000363575,0.0003617696,0.001022086,0.0004389906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249584,"about_ca_system_score_gemma":0.0003229123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000160265,"about_ca_topic_score_gemma":0.00007545509,"domain_scores_codex":[0.9947183,0.001782095,0.0005547967,0.001287276,0.0004295336,0.001227965],"domain_scores_gemma":[0.9982055,0.0003085287,0.0001389898,0.000622147,0.0005104485,0.0002144314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001608001,0.0001561561,0.02787275,0.0003574884,0.00006687557,0.00008766403,0.003745185,0.001940362,0.9619926,0.0001034432,0.0005927291,0.001476703],"study_design_scores_gemma":[0.003010361,0.002917721,0.1070694,0.0006532028,0.000009504402,0.00006369871,0.00110307,0.0000751158,0.8840435,0.00007520624,0.0004506126,0.0005285895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898144,0.005671973,0.00009533902,0.000342193,0.0001029764,0.003310825,0.00009529022,0.0001850166,0.0003819687],"genre_scores_gemma":[0.995949,0.00001041038,0.0003524185,0.00005138808,0.00007985048,0.0006298322,0.0001594698,0.00008397298,0.002683698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07919669,"threshold_uncertainty_score":0.9999129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03735451235421217,"score_gpt":0.2819024788545481,"score_spread":0.2445479665003359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}