{"id":"W3009228664","doi":"10.1002/bdr2.1666","title":"Gestational exposure to valproic acid upregulates total Stat3 protein expression while downregulating phosphorylated Stat3 in CD‐1 mouse embryos with neural tube defects","year":2020,"lang":"en","type":"article","venue":"Birth Defects Research","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Neural tube; STAT3; Embryo; Downregulation and upregulation; STAT protein; Biology; Phosphorylation; Valproic Acid; Andrology; Endocrinology; Embryogenesis; In utero; Internal medicine; Fetus; Medicine; Pregnancy; Cell biology; Biochemistry; Genetics; Epilepsy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008252777,0.0003014461,0.0002140973,0.0003356559,0.0001303077,0.0002243194,0.0001240575,0.000271873,0.001443868],"category_scores_gemma":[0.00007458538,0.0002217923,0.0003052209,0.0001221916,0.0002646183,0.0001393864,0.0001525039,0.000689305,0.00028981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002733672,"about_ca_system_score_gemma":0.0001864667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007317732,"about_ca_topic_score_gemma":0.001667716,"domain_scores_codex":[0.9998801,0.00001180269,0.0000161096,0.00003517427,0.00002745454,0.00002938299],"domain_scores_gemma":[0.999905,0.00001447017,0.00003713327,0.000008781662,0.000006653059,0.00002790993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001380605,0.00001488958,0.0002067103,0.00001580512,0.000002107904,0.00005322814,0.00001610693,0.00001102207,0.9991707,0.00002417361,0.00001367889,0.0003335549],"study_design_scores_gemma":[0.0000203979,0.0004924331,0.01681799,0.00001099738,0.00001808026,0.0003144426,0.00007351101,0.0002567164,0.9805541,0.0000316843,0.001405224,0.000004275933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960865,0.001356393,0.0009027664,0.00007893913,0.00003033225,0.00002172127,0.0006155181,0.00004865387,0.0008593945],"genre_scores_gemma":[0.9886757,0.001801498,0.00216758,0.00009946032,0.00001123696,0.00008070734,0.0009959922,0.00003046745,0.006137433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001443868,"threshold_uncertainty_score":0.004830182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03735451235421217,"score_gpt":0.2819024788545481,"score_spread":0.2445479665003359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}