{"id":"W3009262414","doi":"10.1101/2020.02.22.20026757","title":"Polygenic modulation of lipoprotein(a)-associated cardiovascular risk","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC; Compute Canada; Providence Health Care","keywords":"Lipoprotein(a); Myocardial infarction; Internal medicine; Medicine; Percentile; Lipoprotein; Coronary artery disease; Hazard ratio; Cardiology; Endocrinology; Cholesterol; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006732037,0.0003726585,0.0002586981,0.0004905807,0.000258935,0.0005335317,0.0002049031,0.0003928381,0.001340614],"category_scores_gemma":[0.001445568,0.0001561547,0.0003733711,0.0005373427,0.0004046298,0.0001560999,0.0004414595,0.0003372237,0.0001760787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001723923,"about_ca_system_score_gemma":0.0001972025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003816194,"about_ca_topic_score_gemma":0.002909523,"domain_scores_codex":[0.9993725,0.0003519549,0.00003382966,0.0001247985,0.0000581717,0.0000587126],"domain_scores_gemma":[0.998813,0.0003916467,0.0003750976,0.0001574421,0.00007515342,0.0001876559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007471743,0.0001205723,0.9647813,0.00003768156,0.000944171,0.0004911185,0.0001372395,0.0008209595,0.02211004,0.0005785591,0.0003177125,0.008913492],"study_design_scores_gemma":[0.000008992258,0.00009895556,0.9976242,0.000004990589,0.00008781636,0.0002054782,0.00002467221,0.001185529,0.0002681907,0.0003704619,0.0001153738,0.000005387413],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972206,0.000717302,0.0009617927,0.0001378738,0.00001034477,0.000005904322,0.0002329616,0.0000239711,0.0006892659],"genre_scores_gemma":[0.9992532,0.000145947,0.0003093341,0.00002494678,0.00001133057,0.000003570264,0.0001016159,0.000003391961,0.0001466381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003816194,"threshold_uncertainty_score":0.007587969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01926402143406945,"score_gpt":0.2473656546596226,"score_spread":0.2281016332255532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}