{"id":"W3009265606","doi":"10.1177/0271678x20908523","title":"The cell-permeable mitochondrial calcium uniporter inhibitor Ru265 preserves cortical neuron respiration after lethal oxygen glucose deprivation and reduces hypoxic/ischemic brain injury","year":2020,"lang":"en","type":"article","venue":"Journal of Cerebral Blood Flow & Metabolism","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Uniporter; Oxygen; Respiration; Calcium; Hypoxia (environmental); Neuroscience; Mitochondrion; Neuron; Cellular respiration; Ischemia; Biology; Chemistry; Medicine; Internal medicine; Cell biology; Anatomy; Cytosol; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003544643,0.0002458205,0.0003259571,0.00005859962,0.0001731061,0.0001263244,0.0002523955,0.0002758512,0.00007035287],"category_scores_gemma":[0.0007769261,0.0001804796,0.0001996418,0.0001291829,0.0001370586,0.00005502392,0.0001489706,0.0004599862,0.000007690242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006143285,"about_ca_system_score_gemma":0.000148863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006328281,"about_ca_topic_score_gemma":0.000008153794,"domain_scores_codex":[0.9978523,0.0004249868,0.0007251506,0.000365967,0.0003243041,0.0003073501],"domain_scores_gemma":[0.998822,0.00006347165,0.0003699835,0.0002517223,0.0002231871,0.0002696153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002024423,0.00007226673,0.0004364744,0.00001597428,0.00007190948,0.00001797481,0.0001622092,0.00002880956,0.9781058,0.000018386,0.01821763,0.0008281856],"study_design_scores_gemma":[0.001955569,0.0007797524,0.003151907,0.00001150905,0.0001843207,0.0001173354,0.00004412242,0.0002032742,0.8667989,0.00004239039,0.1265053,0.0002056116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903685,0.003514047,0.0008253768,0.00321558,0.00167281,0.0002465937,0.00002625617,0.000009069441,0.0001217647],"genre_scores_gemma":[0.9877725,0.0004078043,0.002241733,0.002005668,0.007064434,0.00001878648,0.00003623074,0.00003974854,0.0004131505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1113069,"threshold_uncertainty_score":0.7359743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329091102135373,"score_gpt":0.236213577617722,"score_spread":0.2229226665963683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}