{"id":"W3009312185","doi":"10.1158/1078-0432.ccr-19-3087","title":"Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Health and Care Research Wales; Cancer Research Wales; Cancer Research UK; Wellcome Trust; Medical Research Council; Wellcome","keywords":"Antigen; Cancer; Biology; RNA; Immunology; Immunity; Cancer research; Immune system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003453686,0.0003338066,0.0002052042,0.0003774421,0.0002149267,0.0003516536,0.0001477904,0.0002446274,0.0007998873],"category_scores_gemma":[0.0005449218,0.000117365,0.0002172551,0.0002362205,0.000246487,0.0001295272,0.0002137071,0.0003871151,0.0005985376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001529399,"about_ca_system_score_gemma":0.0002212189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002219218,"about_ca_topic_score_gemma":0.0005515868,"domain_scores_codex":[0.9997299,0.00005270386,0.00002007044,0.00007390205,0.00008925884,0.00003414384],"domain_scores_gemma":[0.9997178,0.00009096995,0.00005579788,0.00003995738,0.00007235458,0.00002321368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003660619,0.000005612794,0.0003245173,0.00002248462,0.000003367238,0.00001722424,0.00001341876,0.00006822638,0.997767,0.00004182991,0.00001681867,0.001682881],"study_design_scores_gemma":[0.000008594621,0.0002090476,0.00609652,0.000007843169,0.00002913554,0.0002271191,0.00003778249,0.001930667,0.988074,0.0001414363,0.003233731,0.000004242552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9004721,0.00164614,0.09227373,0.0001669576,0.00006922989,0.0001756644,0.002270135,0.0003097831,0.002616252],"genre_scores_gemma":[0.92171,0.001417198,0.06857312,0.0001871886,0.00005371873,0.0001885057,0.005673705,0.0001275418,0.002069085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007998873,"threshold_uncertainty_score":0.002675891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1325463781197652,"score_gpt":0.4114010023717912,"score_spread":0.278854624252026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}