{"id":"W3009391993","doi":"10.1016/j.jcmgh.2020.02.007","title":"A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration","year":2020,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Liver physiology and pathology","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Organoid; Regeneration (biology); Intestinal epithelium; Cell biology; Regulator; Biology; Intestinal mucosa; Stem cell; Immunology; Epithelium; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257597,0.000155834,0.0005445738,0.00007652782,0.00005315595,0.000002511382,0.00004831079,0.0002208082,0.0000151396],"category_scores_gemma":[0.0001621333,0.000147018,0.00007005823,0.00003761479,0.001182367,0.00003921209,0.0001348048,0.0002056497,8.390004e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003128731,"about_ca_system_score_gemma":0.00004637525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001561631,"about_ca_topic_score_gemma":0.00000728486,"domain_scores_codex":[0.9988821,0.0001458656,0.0003245664,0.0003773653,0.00006044119,0.0002097237],"domain_scores_gemma":[0.999451,0.00005157808,0.00009396706,0.0001559852,0.0001003576,0.0001470633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001620138,0.00009730298,0.0419715,0.0003286985,0.00009282723,0.0001532158,0.0005341214,0.000008049574,0.9469768,0.008153686,0.00003800825,0.00002558124],"study_design_scores_gemma":[0.006226133,0.00872668,0.02262083,0.0001031143,0.001146126,0.00395645,0.0002664949,0.06367654,0.887006,0.005965251,0.00004379638,0.0002625533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9565581,0.0004960024,0.04029229,0.002399312,0.00005036059,0.0001372256,0.00001954509,0.00002021725,0.00002696334],"genre_scores_gemma":[0.9923737,0.0000941308,0.005004545,0.002436707,0.0000298662,0.000006566444,0.00003005162,0.00001241478,0.00001203238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0636685,"threshold_uncertainty_score":0.5995221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01635482399249187,"score_gpt":0.2443294302087191,"score_spread":0.2279746062162272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}