{"id":"W3009588214","doi":"10.7554/elife.52189.sa2","title":"Author response: Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism","year":2020,"lang":"en","type":"peer-review","venue":"","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"","keywords":"Agonism; Dopamine receptor D3; Chemistry; Dopamine receptor D2; Dopamine; Neuroscience; Stereochemistry; Biology; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001360616,0.0009311816,0.0009076907,0.0005917075,0.001072455,0.002260536,0.00101808,0.008164836,0.2631035],"category_scores_gemma":[0.01235433,0.0003651376,0.001013068,0.0003802086,0.001073248,0.001170943,0.001684701,0.005412236,0.08884645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001387793,"about_ca_system_score_gemma":0.001577566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0018062,"about_ca_topic_score_gemma":0.00289052,"domain_scores_codex":[0.9985618,0.0004176107,0.0001023625,0.0002523821,0.0004257988,0.0002400966],"domain_scores_gemma":[0.994837,0.00194297,0.0003677891,0.0001733548,0.002001159,0.0006777841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002985426,0.00002233239,0.0003141439,0.0002711687,0.00001631748,0.0001160963,0.00003952978,0.00008583286,0.0002055608,0.0003702808,0.9894532,0.008807119],"study_design_scores_gemma":[0.0003476485,0.0001631303,0.002174775,0.000602863,0.00003967342,0.0003152133,0.0005964343,0.0002909994,0.0006472949,0.001826317,0.992938,0.00005762433],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.004048678,0.006357274,0.001513193,0.6456691,0.2589353,0.0005066534,0.007278251,0.001754194,0.07393735],"genre_scores_gemma":[0.0425213,0.00841169,0.001905445,0.537574,0.06874682,0.0007733372,0.004714077,0.0008069594,0.3345464],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2631035,"threshold_uncertainty_score":0.880169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745632606603378,"score_gpt":0.2966940789380604,"score_spread":0.2692377528720267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}