{"id":"W3009636168","doi":"10.1158/0008-5472.bcd-19-0039","title":"Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on <i>MIR300</i> Antiproliferative and PP2A-Activating Functions","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute; National Institutes of Health; Cancer Research Society; National Natural Science Foundation of China; American Cyronics Society; U.S. Department of Defense","keywords":"Progenitor cell; Cancer research; Protein phosphatase 2; Biology; Stem cell; Immune system; Immunology; Leukemia; Apoptosis; Cell biology; Phosphatase; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009261814,0.0001555447,0.0002001554,0.0002276143,0.0001431669,0.0002455553,0.00008158457,0.0001613394,0.001584756],"category_scores_gemma":[0.0001813252,0.00008217274,0.0001274558,0.0001486215,0.000149769,0.0001222594,0.0001013837,0.0003107491,0.0002681436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002030615,"about_ca_system_score_gemma":0.0001072374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001957663,"about_ca_topic_score_gemma":0.0002159013,"domain_scores_codex":[0.9999244,0.000009248823,0.000009130494,0.00001992143,0.00002307244,0.00001409027],"domain_scores_gemma":[0.9999137,0.00001182352,0.00003718438,0.000005810251,0.000008076457,0.00002338632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003117805,0.0001936358,0.1483247,0.00008815686,0.00005370297,0.001030527,0.0000989846,0.0001778284,0.8147753,0.0003023523,0.0007256265,0.03111131],"study_design_scores_gemma":[0.0001469564,0.001781617,0.719964,0.00001936404,0.0001291177,0.01167728,0.0001337046,0.001733185,0.2572059,0.0004314262,0.006757644,0.00001995231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976491,0.0006227272,0.0004490383,0.0000682059,0.000006848444,0.00001535762,0.0002173831,0.00004065325,0.0009305024],"genre_scores_gemma":[0.9990344,0.0001177419,0.000247724,0.00003481547,0.00000755266,0.0000101861,0.0002189825,0.000004563984,0.0003240243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001584756,"threshold_uncertainty_score":0.005301595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585045797614332,"score_gpt":0.2071715928590338,"score_spread":0.1913211348828905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}