{"id":"W3009636168","doi":"10.1158/0008-5472.bcd-19-0039","title":"Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on <i>MIR300</i> Antiproliferative and PP2A-Activating Functions","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute; National Institutes of Health; Cancer Research Society; National Natural Science Foundation of China; American Cyronics Society; U.S. Department of Defense","keywords":"Progenitor cell; Cancer research; Protein phosphatase 2; Biology; Stem cell; Immune system; Immunology; Leukemia; Apoptosis; Cell biology; Phosphatase; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008474252,0.0002012346,0.0003082204,0.00007961464,0.0001785541,0.0000320108,0.00008511357,0.0001028031,0.00006294644],"category_scores_gemma":[0.00001754482,0.0001854489,0.00006625958,0.0001543571,0.0001093275,0.0003797891,0.00008528562,0.0003684027,0.0000103427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000678327,"about_ca_system_score_gemma":0.00009166687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006271534,"about_ca_topic_score_gemma":0.0000978453,"domain_scores_codex":[0.9988434,0.0001947571,0.0003456216,0.0003433558,0.000052925,0.0002199563],"domain_scores_gemma":[0.9993977,0.0001289825,0.0002307854,0.0001487199,0.00006445723,0.00002938665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001528649,0.0003322152,0.0194935,0.0001536856,0.0001238696,0.000001362809,0.003105534,0.00005794024,0.9735907,0.00001044467,0.0007017238,0.0009003195],"study_design_scores_gemma":[0.003869903,0.0007996827,0.02006562,0.0002136558,0.0000946061,0.000002959621,0.00771739,0.00003434422,0.9656547,0.000002167617,0.001291096,0.000253845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957305,0.002609786,0.00001574537,0.00009671699,0.0006117243,0.0002880314,0.0001138902,0.00002080587,0.0005127537],"genre_scores_gemma":[0.9978356,0.0005793255,0.000005408554,0.0002817642,0.0000181108,0.00002995559,0.00004599723,0.00001630876,0.001187563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007936031,"threshold_uncertainty_score":0.7562388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585045797614332,"score_gpt":0.2071715928590338,"score_spread":0.1913211348828905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}