{"id":"W3009729700","doi":"10.1158/1055-9965.epi-19-1346","title":"The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them","year":2020,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Cancer Centre","funders":"National Institute of Environmental Health Sciences; National Institutes of Health; California Environmental Protection Agency; World Health Organization","keywords":"Carcinogenesis; Cancer; Identification (biology); Computational biology; Carcinogen; Cancer biomarkers; Hazard; Bioinformatics; Biology; Medicine; Risk analysis (engineering); Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02867354,0.001011292,0.001196783,0.01212904,0.001190656,0.005644751,0.00169061,0.002033707,0.003133073],"category_scores_gemma":[0.05098314,0.000768917,0.001266968,0.006313871,0.004325885,0.005397372,0.003015537,0.004360368,0.001291719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003597175,"about_ca_system_score_gemma":0.007785908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005255518,"about_ca_topic_score_gemma":0.01328252,"domain_scores_codex":[0.9784912,0.01065901,0.002511847,0.0016106,0.006269262,0.0004581009],"domain_scores_gemma":[0.926109,0.03440098,0.0112757,0.004707806,0.02250787,0.0009987534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005273246,0.0003071701,0.1991345,0.01697777,0.0006834893,0.0006927303,0.002177233,0.005860515,0.03473957,0.09037898,0.04032943,0.6081914],"study_design_scores_gemma":[0.00007877198,0.001287887,0.2225014,0.01387122,0.001418934,0.005088276,0.008312786,0.008491451,0.07503003,0.1517704,0.5115448,0.0006039925],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07951968,0.3838206,0.3452799,0.1016603,0.004654414,0.002208187,0.007660548,0.0008228996,0.07437353],"genre_scores_gemma":[0.5536718,0.1400323,0.2727245,0.01586162,0.002470979,0.001148997,0.0025943,0.0002697201,0.01122577],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02867354,"threshold_uncertainty_score":0.151642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0689058833321833,"score_gpt":0.3341805811452753,"score_spread":0.265274697813092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}