{"id":"W3009738017","doi":"10.1017/cjn.2019.125","title":"P.025 APOLLO, a phase 3 study of patisiran for the treatment of hereditary transthyretin amyloidosis (hATTR): 18-month safety and efficacy in subgroup with cardiac involvement","year":2019,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cardiac amyloidosis; Medicine; Placebo; Amyloidosis; Cardiomyopathy; Cardiology; Transthyretin; Internal medicine; Cardiac function curve; Heart failure; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007524148,0.0006625354,0.0006392344,0.0002273258,0.0002402692,0.0006262193,0.0003967087,0.0007476389,0.006775904],"category_scores_gemma":[0.0004257543,0.0002256494,0.0007911632,0.0001694993,0.0004016116,0.0003567111,0.000148369,0.001564133,0.0008911947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002909193,"about_ca_system_score_gemma":0.0006148554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004543885,"about_ca_topic_score_gemma":0.001468894,"domain_scores_codex":[0.9998711,0.00005213005,0.000008363206,0.00002673147,0.00002168461,0.00001997177],"domain_scores_gemma":[0.999762,0.00004791606,0.00006221062,0.00001653921,0.00002684543,0.00008452586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6247591,0.0337214,0.008443401,0.001856493,0.002522213,0.0004906963,0.0002512101,0.001140621,0.1200512,0.0007421437,0.01529418,0.1907272],"study_design_scores_gemma":[0.6093335,0.345425,0.02364925,0.00008843926,0.0009685797,0.0005104864,0.00007472931,0.001633783,0.00906867,0.0004985761,0.008713415,0.00003561858],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842523,0.003229184,0.0009071424,0.0008154513,0.0001672619,0.001755683,0.002887568,0.0003344391,0.005650931],"genre_scores_gemma":[0.981495,0.00171174,0.002145642,0.001617231,0.0001591728,0.002049539,0.003289296,0.00004794476,0.007484443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006775904,"threshold_uncertainty_score":0.02266771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239118006098025,"score_gpt":0.2781758123443542,"score_spread":0.2542640117345517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}