{"id":"W3009747044","doi":"10.1101/2020.01.23.20018507","title":"The cholinergic system and treatment response in subtypes of Alzheimer’s disease","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; University of California, San Diego; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; National Institutes of Health; Servier; Karolinska Institutet; Vetenskapsrådet; Eisai; Genentech; Stiftelsen för Strategisk Forskning; Northern California Institute for Research and Education; Stockholms Läns Landsting; Pfizer; Biogen; BioClinica; IXICO; Alzheimer's Association; Åke Wiberg Stiftelse; F. Hoffmann-La Roche; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Synarc; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Foundation for the National Institutes of Health","keywords":"Precuneus; Basal forebrain; Atrophy; Hippocampus; Cholinergic neuron; Cholinergic; Internal medicine; Neuroscience; Alzheimer's disease; Medicine; Pathology; Psychology; Disease; Cognition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001312536,0.0002373667,0.0007546829,0.0003443338,0.0002090377,0.0003491281,0.0002951099,0.0004412315,0.0007692948],"category_scores_gemma":[0.001599496,0.0000974071,0.0003795428,0.0002371588,0.0001836455,0.0002218054,0.000151232,0.0003131835,0.0001550257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003034917,"about_ca_system_score_gemma":0.0001869493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001098154,"about_ca_topic_score_gemma":0.001832366,"domain_scores_codex":[0.9995539,0.0001981679,0.00006982256,0.00006031591,0.00006908747,0.00004867516],"domain_scores_gemma":[0.9991971,0.000213563,0.0003131695,0.00006930693,0.000110169,0.00009673988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1202383,0.002542142,0.6931165,0.0006078494,0.001743909,0.0003533498,0.000345486,0.0007457035,0.02221535,0.00007870729,0.0003805595,0.1576321],"study_design_scores_gemma":[0.001166732,0.0143094,0.9806528,0.00004775096,0.0003153854,0.0004282579,0.0001128065,0.000377504,0.001904186,0.0001311596,0.0005420505,0.00001191391],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953173,0.003823979,0.00007358645,0.00003906724,0.000007914859,0.00004792108,0.00009639421,0.000003647095,0.0005900217],"genre_scores_gemma":[0.9989728,0.0004349789,0.0001202889,0.00003697285,0.00001510274,0.00003541295,0.0001621191,0.000001101437,0.0002212613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001312536,"threshold_uncertainty_score":0.006941438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05724018135840561,"score_gpt":0.3339027107316965,"score_spread":0.2766625293732908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}