{"id":"W3009777504","doi":"10.1016/s1470-2045(20)30092-9","title":"Statistical significance and clinical evidence – Authors' reply","year":2020,"lang":"en","type":"letter","venue":"The Lancet Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Observational study; Medicine; Confounding; Bonferroni correction; Clinical trial; Randomized controlled trial; Publication bias; Alternative medicine; Medical physics; Family medicine; Meta-analysis; Internal medicine; Statistics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03792154,0.001399518,0.005345099,0.002999666,0.006134634,0.0109767,0.004964251,0.1400859,0.009856057],"category_scores_gemma":[0.2525188,0.002848688,0.003306106,0.003229683,0.01212796,0.008077652,0.005978604,0.1183067,0.008976961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008425844,"about_ca_system_score_gemma":0.01478385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00809257,"about_ca_topic_score_gemma":0.0104804,"domain_scores_codex":[0.9616611,0.01527529,0.007046016,0.00433445,0.009031583,0.002651583],"domain_scores_gemma":[0.7411412,0.2069671,0.01082964,0.006134814,0.02331356,0.01161376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008273663,0.00001327781,0.0003046651,0.0001026291,0.00005045237,0.0002320152,0.0001148528,0.00004644367,0.00004480904,0.003115326,0.992269,0.003623715],"study_design_scores_gemma":[0.0006828669,0.0000836895,0.001371987,0.001704349,0.0002374926,0.0008816809,0.0005277485,0.0006639647,0.0002439747,0.04005332,0.9533082,0.0002406579],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00005348314,0.0007973914,0.00008150315,0.9720088,0.02657008,0.00001100757,0.0000597066,0.00001343321,0.0004045954],"genre_scores_gemma":[0.0005886037,0.0002843043,0.0001475929,0.9607384,0.03724265,0.00004987886,0.00001780578,0.00001867183,0.0009121295],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1400859,"threshold_uncertainty_score":0.2005506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8081831323988989,"score_gpt":0.6434700718790197,"score_spread":0.1647130605198792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}