{"id":"W3009779840","doi":"10.1101/2020.03.04.976019","title":"Type I toxin-antitoxin systems contribute to mobile genetic elements maintenance in <i>Clostridioides difficile</i> and can be used as a counter-selectable marker for chromosomal manipulation","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Prophage; Antitoxin; Biology; Mobile genetic elements; Gene; Genetics; Toxin; Lysogenic cycle; Genome; Microbiology; Escherichia coli; Bacteriophage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000146534,0.0004413629,0.0002090331,0.00038986,0.0002617994,0.0003243629,0.0002259968,0.0002962281,0.000619175],"category_scores_gemma":[0.0002236903,0.0001598011,0.0002820631,0.0003310519,0.0001933457,0.0001316156,0.0003143879,0.0004549118,0.0002686006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003190521,"about_ca_system_score_gemma":0.0002437438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001442528,"about_ca_topic_score_gemma":0.001425517,"domain_scores_codex":[0.9997839,0.00003200002,0.00002327152,0.00003769021,0.00006370941,0.00005936122],"domain_scores_gemma":[0.9997265,0.00005159674,0.0000893344,0.00002519689,0.00003874439,0.00006858887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003024043,0.000008680188,0.0002012547,0.00001017521,0.000001228992,0.00001849342,0.000008429454,0.00001381729,0.9991053,0.00001933106,0.00000902676,0.0005741371],"study_design_scores_gemma":[0.000009952367,0.0001727383,0.01247308,0.000009175477,0.000022623,0.0003342192,0.00005335479,0.0003087657,0.9849774,0.00002892457,0.001602942,0.000006872482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924906,0.000519017,0.005361657,0.00006912187,0.00002940765,0.00005117065,0.0004478398,0.00007780027,0.0009533743],"genre_scores_gemma":[0.9904727,0.0002569869,0.006289352,0.00003372733,0.00000886388,0.00004012104,0.00126725,0.00003958432,0.001591472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442528,"threshold_uncertainty_score":0.002868295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230958799317602,"score_gpt":0.268377940624021,"score_spread":0.2452820606922608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}