{"id":"W3009800781","doi":"10.1002/gepi.22288","title":"Transcriptome‐wide association study of breast cancer risk by estrogen‐receptor status","year":2020,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université Laval; BC Cancer Agency; Centre hospitalier universitaire de Québec; McGill University; University Health Network; University of Toronto; Royal Victoria Hospital; Queen's University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Medical Research and Materiel Command; Fogarty International Center; National Institute of General Medical Sciences; NIH Office of the Director; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; Servicio Gallego de Salud; Instituto de Salud Carlos III; Cancer Council Western Australia; Cancer Council NSW; Cancer Council Victoria; World Cancer Research Fund; Medical Research Council; Hellenic Health Foundation; Freistaat Sachsen; Institut Català de la Salut; Centro de Investigación Biomédica en Red de Cáncer; Biomedical Research Council; Federal Agency for Scientific Organizations; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; Radboud Universitair Medisch Centrum; National Health and Medical Research Council; Ministry of Education, Science and Technology; Academia Sinica; Deutsche Krebshilfe; Cancer Institute NSW; Medizinischen Hochschule Hannover; Cancer Council South Australia; Centre International de Recherche sur le Cancer; Kreftforeningen; Institut National Du Cancer; Oak Foundation; Leids Universitair Medisch Centrum; Karolinska Institutet; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; Vetenskapsrådet; Fondation de France; Stavros Niarchos Foundation; University of Westminster; Ligue Contre le Cancer; Korea Health Industry Development Institute; Hungarian Scientific Research Fund; Ministerio de Economía y Competitividad; Erasmus Medisch Centrum; Japan Agency for Medical Research and Development; Deutsche Gesetzliche Unfallversicherung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; King's College London; Fondation ARC pour la Recherche sur le Cancer; Gentofte Hospital; California Breast Cancer Research Program; Generalitat de Catalunya; Alexander von Humboldt-Stiftung; Cancerfonden; American Cancer Society; Cancer Australia; Radboud Universiteit; Russian Foundation for Basic Research; Kuopion Yliopistollinen Sairaala; National Medical Research Council; Norges Forskningsråd; Stockholms Läns Landsting; Universiteit Maastricht; Vrije Universiteit Amsterdam; Academy of Finland; Maastricht Universitair Medisch Centrum; National Heart, Lung, and Blood Institute; Ohio State University; Universiteit Leiden; University of Crete; Institut National de la Santé et de la Recherche Médicale; Agency for Science, Technology and Research; Canadian Institutes of Health Research; European Commission; Avon Foundation for Women; Breast Cancer Research Trust; Fondation du cancer du sein du Québec; National Cancer Institute; European Regional Development Fund; Ministerio de Sanidad, Servicios Sociales e Igualdad; University of Cambridge; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Virginia Department of Health; Government of Canada; Georgetown University; Breast Cancer Campaign; National Research Foundation; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Breast Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; National Institute of Environmental Health Sciences; Swedish Cancer Foundation; Lon V. Smith Foundation; Fundación Mutua Madrileña; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Institute of Biomedical Sciences, Academia Sinica; David F. and Margaret T. Grohne Family Foundation; Consejo Nacional de Ciencia y Tecnología; Sundhed og Sygdom, Det Frie Forskningsråd; Deutsches Krebsforschungszentrum; University College London; National Research Foundation of Korea; California Department of Public Health; Genome Canada; Cancer Council Tasmania; Itä-Suomen Yliopisto; Programme Grants for Applied Research; Robert Bosch Stiftung; Center for Agroforestry, University of Missouri; Oulun Yliopisto; Fundación Cellex; Fisher Center for Alzheimer's Research Foundation; Centers for Disease Control and Prevention; National Institute for Health and Care Research; Susan G. Komen for the Cure; Taiwan Biobank; U.S. Department of Health and Human Services; Agence Nationale de la Recherche; U.S. Army; Landspítali Háskólasjúkrahús; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Ministry of Education, Culture, Sports, Science and Technology; Ovarian Cancer Research Fund; National Institutes of Health; Division of Cancer Prevention, National Cancer Institute; Cancer Research UK; Breast Cancer Research Foundation; Rijksuniversiteit Groningen; Deutscher Akademischer Austauschdienst; Yayasan Sime Darby; Xunta de Galicia; Dr. Ralph and Marian Falk Medical Research Trust; Fonds Wetenschappelijk Onderzoek","keywords":"Breast cancer; Genome-wide association study; Estrogen receptor; Transcriptome; Biology; Genetic association; Oncology; Gene; Cancer; Estrogen receptor alpha; Genetics; Computational biology; Medicine; Single-nucleotide polymorphism; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00118366,0.0002360746,0.0004788139,0.0006808444,0.0003255265,0.0004959026,0.0002113932,0.0001972896,0.001536175],"category_scores_gemma":[0.001659573,0.0001898609,0.0009788511,0.001440763,0.0001880621,0.0001612403,0.0004428327,0.0004137476,0.0001724832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000182169,"about_ca_system_score_gemma":0.0003462987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002540437,"about_ca_topic_score_gemma":0.004718506,"domain_scores_codex":[0.9993012,0.0003179214,0.00004942805,0.0001864262,0.00008333546,0.00006156186],"domain_scores_gemma":[0.9989643,0.0004891458,0.000204485,0.0001901867,0.00007369567,0.00007823078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008570906,0.00004507327,0.9362595,0.0001000619,0.003449935,0.0003001647,0.00009595541,0.0009293748,0.04968966,0.0002904635,0.0005211523,0.007461656],"study_design_scores_gemma":[0.000025252,0.00008347847,0.9939007,0.000007154445,0.0009038527,0.0002903912,0.0000794542,0.001387179,0.002356636,0.0002742965,0.0006832069,0.000008399637],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936139,0.0006820822,0.003365605,0.00009485216,0.0000139037,0.000009012196,0.001774465,0.00004246989,0.0004037852],"genre_scores_gemma":[0.9969273,0.0002581431,0.001101806,0.00003887916,0.000008725153,0.00002172015,0.001349134,0.00001662068,0.0002777571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002540437,"threshold_uncertainty_score":0.006259859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01675303260110503,"score_gpt":0.2821266363232841,"score_spread":0.2653736037221791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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