{"id":"W3009846583","doi":"10.1101/gad.332643.119","title":"The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice","year":2020,"lang":"en","type":"article","venue":"Genes & Development","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Fondation ARC pour la Recherche sur le Cancer; Ministerio de Ciencia e Innovación; Université de Strasbourg; Generalitat de Catalunya; Agence Nationale de la Recherche; Centre de Regulació Genòmica; Fondation Schlumberger pour l’Education et la Recherche; Centres de Recerca de Catalunya","keywords":"Senescence; Biology; Regeneration (biology); Cell biology; Liver regeneration; Cellular senescence; Gene expression; Cancer research; Gene; Phenotype; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001589634,0.0004510148,0.0003434645,0.00071675,0.0002181507,0.0001741877,0.0002027492,0.0002885454,0.002061481],"category_scores_gemma":[0.00006626766,0.0001913067,0.0002814901,0.0002282724,0.0003454179,0.0001963282,0.0001426179,0.0007909578,0.0004068154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002326855,"about_ca_system_score_gemma":0.0003068694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006136049,"about_ca_topic_score_gemma":0.001706673,"domain_scores_codex":[0.999899,0.00001577628,0.00001160369,0.00001771979,0.00002288192,0.00003306047],"domain_scores_gemma":[0.999895,0.00001316594,0.00002818316,0.000008709139,0.000006464761,0.00004855627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003607135,0.00009454983,0.0001334471,0.0000362905,0.000009701163,0.00006615704,0.000012002,0.0001154291,0.9963244,0.0001837471,0.00008394869,0.002579644],"study_design_scores_gemma":[0.00007381876,0.001630802,0.002801624,0.00000936869,0.0000314097,0.0002000531,0.00002152362,0.0008120199,0.9912733,0.00008581553,0.003054124,0.000006074415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928541,0.001917453,0.001695613,0.0002095299,0.00006505002,0.00004866462,0.0005681665,0.0002659664,0.002375481],"genre_scores_gemma":[0.9905301,0.001978561,0.001742662,0.0001082185,0.0000214894,0.00007876666,0.0004740435,0.00005127806,0.005014902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002061481,"threshold_uncertainty_score":0.006896377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02599069254013985,"score_gpt":0.2592367546988171,"score_spread":0.2332460621586773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}