{"id":"W3009883572","doi":"10.1139/cjc-2020-0029","title":"Identification of a C2′<b>-</b>fluorinated SAH analogue","year":2020,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Toronto; Structural Genomics Consortium; Université de Montréal; Montreal Clinical Research Institute","funders":"Novartis Pharma; Ontario Ministry of Research, Innovation and Science; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genome Canada; Ontario Genomics; Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Chemistry; Moiety; Stereochemistry; Nucleoside; Methyltransferase; Methylation; Amine gas treating; Formylation; Lysine; Cofactor; Biochemistry; Enzyme; DNA; Amino acid; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001650143,0.0003250371,0.0003221308,0.0002321399,0.0001685923,0.0002043167,0.0003611405,0.0004409081,0.002039817],"category_scores_gemma":[0.0001785033,0.0001151814,0.0002291154,0.0001705692,0.0001852125,0.0001937844,0.000165609,0.0004935123,0.0005213917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003365563,"about_ca_system_score_gemma":0.0002220703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007888644,"about_ca_topic_score_gemma":0.001152895,"domain_scores_codex":[0.9999125,0.00002059242,0.000006471721,0.00001766317,0.00001657344,0.00002620013],"domain_scores_gemma":[0.9999151,0.00001613204,0.00001496724,0.000007745981,0.00002221917,0.0000238177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003379498,0.00004720893,0.0001848038,0.0001524919,0.00001521973,0.0003397041,0.00003547878,0.0004957812,0.9867944,0.0004711469,0.000134422,0.01099141],"study_design_scores_gemma":[0.00005757558,0.001356079,0.0007354929,0.00001153395,0.00002024708,0.0005907347,0.00001448181,0.0004147443,0.9873446,0.00009409103,0.009349633,0.0000107632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9473665,0.01270771,0.02416009,0.0003491292,0.0001414898,0.0002634046,0.001148243,0.0002266173,0.01363679],"genre_scores_gemma":[0.9814683,0.002525975,0.01215584,0.0001151831,0.00002633491,0.0000479408,0.0007321828,0.00002433034,0.002903885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002039817,"threshold_uncertainty_score":0.006823897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090787211889757,"score_gpt":0.2224321275240454,"score_spread":0.2115242554051479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}