{"id":"W3009891869","doi":"10.1158/1538-7445.sabcs19-gs4-01","title":"Abstract GS4-01: Ten-year results from NRG Oncology/NSABP B-42: A randomized, double-blinded, placebo-controlled clinical trial of extended adjuvant endocrine therapy with letrozole (L) in postmenopausal women with hormone-receptor+ breast cancer (BC) who have completed previous adjuvant therapy with an aromatase inhibitor (AI)","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Letrozole; Internal medicine; Clinical endpoint; Statistical significance; Breast cancer; Oncology; Placebo; Tamoxifen; Hormonal therapy; Randomized controlled trial; Cancer; Gastroenterology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.003400692,0.001050194,0.005044139,0.0005357411,0.0002289234,0.0001215761,0.0008168154,0.00037335,0.0008361173],"category_scores_gemma":[0.0002141518,0.0006345237,0.0002637981,0.001180475,0.002246112,0.0005840071,0.0001464693,0.002754687,0.00001664521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001428153,"about_ca_system_score_gemma":0.004652076,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0125627,"about_ca_topic_score_gemma":0.002790975,"domain_scores_codex":[0.9892361,0.001861778,0.002435807,0.002053153,0.002561277,0.001851919],"domain_scores_gemma":[0.993026,0.001740257,0.001166587,0.001385113,0.001405548,0.001276545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9303123,0.00354781,0.001495158,0.00008600487,0.002908176,0.0006092613,0.00362145,0.0003153147,0.01073612,0.00001081208,0.000408137,0.04594947],"study_design_scores_gemma":[0.9388886,0.03936064,0.0122459,0.0009854964,0.0001812565,0.00006247305,0.002397907,0.000326145,0.00288375,0.00003413678,0.001885753,0.0007479592],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674463,0.005866466,0.00004140263,0.00789256,0.0001555136,0.01595786,0.002298035,0.0001579561,0.0001838918],"genre_scores_gemma":[0.9802397,0.007363395,0.0005800985,0.0009266406,0.001878732,0.0082702,0.0003716795,0.0002762556,0.00009328394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04520152,"threshold_uncertainty_score":0.9996106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09348842831903145,"score_gpt":0.4190237873823928,"score_spread":0.3255353590633614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}