{"id":"W3009968727","doi":"10.1007/s00249-020-01424-1","title":"Symmetry-breaking transitions in the early steps of protein self-assembly","year":2020,"lang":"en","type":"article","venue":"European Biophysics Journal","topic":"Supramolecular Self-Assembly in Materials","field":"Materials Science","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; University of Waterloo","funders":"Università di Catania","keywords":"Chemistry; Peptide; Amyloid (mycology); Population; Molecular dynamics; Crystallography; Protein aggregation; Dimer; Monomer; Biophysics; Chemical physics; Computational chemistry; Biochemistry; Polymer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002970004,0.0002130575,0.0002711756,0.0003360868,0.0006390662,0.000903041,0.0005765318,0.0004799567,0.003735042],"category_scores_gemma":[0.001247356,0.0002528717,0.0002789247,0.0001717617,0.001031923,0.001588126,0.0006419699,0.001321104,0.0005306868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004509806,"about_ca_system_score_gemma":0.0003669754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002930368,"about_ca_topic_score_gemma":0.0002635329,"domain_scores_codex":[0.9998819,0.00001710118,0.000004368782,0.00001798988,0.00003173091,0.00004693212],"domain_scores_gemma":[0.9997337,0.000122505,0.0000311731,0.00004202896,0.00002057218,0.00004990853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005456243,0.0003759378,0.002495189,0.0001980605,0.00002945353,0.0006817206,0.0009459613,0.01727501,0.2403392,0.7024431,0.002726803,0.03194391],"study_design_scores_gemma":[0.0001327343,0.0005473856,0.00731917,0.00003984163,0.00001657381,0.0005977759,0.0005768398,0.1461766,0.1517006,0.688436,0.004329894,0.0001266655],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643791,0.0009207316,0.01759055,0.0005934811,0.0001822107,0.0000291937,0.00006028486,0.0002831325,0.01596136],"genre_scores_gemma":[0.997401,0.0001392166,0.001313495,0.00003548002,0.00001561262,0.00001050938,0.00002837441,0.00003035624,0.00102596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003735042,"threshold_uncertainty_score":0.01249492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871905725394624,"score_gpt":0.2292448200604563,"score_spread":0.2105257628065101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}