{"id":"W3009969158","doi":"10.1158/1538-7445.sabcs19-pd4-02","title":"Abstract PD4-02: Canadian cancer trials group trial IND.231: A phase 1 trial evaluating CX-5461, a novel first-in-class G-quadruplex stabilizer in patients with advanced solid tumors enriched for DNA-repair deficiencies","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Princess Margaret Cancer Centre; BC Cancer Agency; Ottawa Hospital","funders":"","keywords":"Medicine; Toxicity; Internal medicine; Cancer; Clinical trial; Gastroenterology; Oncology; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001018997,0.00106616,0.0009596851,0.0003125822,0.0005966381,0.0007015758,0.0008719288,0.0009668275,0.007754213],"category_scores_gemma":[0.0007067645,0.0002762237,0.0006125765,0.0003734094,0.0006821641,0.0003244749,0.000237441,0.00263935,0.0007780989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003043937,"about_ca_system_score_gemma":0.006202339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02519979,"about_ca_topic_score_gemma":0.06291842,"domain_scores_codex":[0.9996589,0.0001463969,0.00001057871,0.00004691995,0.00005081944,0.00008641018],"domain_scores_gemma":[0.9996628,0.00004959914,0.00004527464,0.00001677546,0.0000390878,0.0001864537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7038491,0.01667104,0.005600456,0.0026582,0.001790664,0.0003510079,0.0002159792,0.003908281,0.03106326,0.001493998,0.06747713,0.1649209],"study_design_scores_gemma":[0.7850637,0.1675436,0.01429627,0.0001279803,0.0008144461,0.0002865709,0.00005843028,0.00194745,0.004585375,0.000543301,0.02468316,0.00004961937],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9443419,0.01009933,0.001002085,0.004907204,0.0003874438,0.006220512,0.009705944,0.000433476,0.02290205],"genre_scores_gemma":[0.960314,0.003520692,0.002582138,0.002804426,0.0001879717,0.003858477,0.007089428,0.00004975324,0.01959304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02519979,"threshold_uncertainty_score":0.05010617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1246246547554847,"score_gpt":0.4319854546255928,"score_spread":0.3073607998701081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}