{"id":"W3009979729","doi":"10.3389/fgene.2020.00170","title":"Pioneering Informed Consent for Return of Research Results to Breast Cancer Patients Facing Barriers to Implementation of Genomic Medicine: The Kenyan BRCA1/2 Testing Experience Using Whole Exome Sequencing","year":2020,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Cancer Association of South Africa; South African Medical Research Council; Universiteit Stellenbosch; DNA Genotek","keywords":"Breast cancer; Informed consent; Medicine; Kenya; Exome sequencing; Family medicine; Exome; Oncology; Cancer; Referral; Family history; Internal medicine; Gynecology; Alternative medicine; Pathology; Biology; Genetics; Mutation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004081742,0.0001291072,0.0001868854,0.0001423998,0.0001244817,0.0000128576,0.0003103302,0.00006820207,0.000004340846],"category_scores_gemma":[0.001212904,0.0001209225,0.00003137716,0.0005075036,0.0001573744,0.000007090573,0.0001906646,0.00008962127,1.719133e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004026948,"about_ca_system_score_gemma":0.001098282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003521918,"about_ca_topic_score_gemma":0.0002323542,"domain_scores_codex":[0.998399,0.00006184804,0.0005918528,0.0003306456,0.0002922625,0.0003243765],"domain_scores_gemma":[0.9988429,0.00007460325,0.0001837159,0.0002543606,0.0004789007,0.0001655137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001939952,0.000004386333,0.09865547,0.0001121196,0.00003254283,2.615623e-7,0.02182865,0.05313514,0.8193068,7.831709e-7,0.002201578,0.004528287],"study_design_scores_gemma":[0.002840226,0.001051915,0.06020104,0.0004233776,0.00004594881,0.000003729622,0.09100881,0.01311221,0.8269666,0.00003017495,0.00387988,0.0004360712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867241,0.0002732189,0.01072325,0.0006533293,0.0003450383,0.0009216957,0.0003366768,0.000004220734,0.00001851329],"genre_scores_gemma":[0.9660745,0.00005376982,0.03326155,0.0002965321,0.0001456708,0.0001026547,0.00003457731,0.0000243722,0.000006323266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06918017,"threshold_uncertainty_score":0.4931075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0812659173063823,"score_gpt":0.3844664943834489,"score_spread":0.3032005770770666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}