{"id":"W3010008632","doi":"10.1073/pnas.1919211117","title":"Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; Government of Canada; Center for AIDS Research, University of Alabama at Birmingham; South African Medical Research Council; National Research Foundation; National Institutes of Health; University of Alabama at Birmingham; Center for AIDS Research, University of Washington; University of Alabama; Natural Sciences and Engineering Research Council of Canada; CRDF Global; National Institute of Diabetes and Digestive and Kidney Diseases; Bill and Melinda Gates Foundation","keywords":"Immune system; Glycolysis; Innate immune system; Mycobacterium tuberculosis; Effector; Pentose phosphate pathway; Tuberculosis; Pathogenesis; Biology; Immunology; Microbiology; Medicine; Metabolism; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001268458,0.000259881,0.0002021838,0.0001811502,0.00009278928,0.0002014531,0.0001304599,0.000318652,0.00117349],"category_scores_gemma":[0.0001186909,0.00009185075,0.0001599969,0.00008337868,0.0002795028,0.0001147277,0.0001822383,0.0004326964,0.0001690242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001898262,"about_ca_system_score_gemma":0.0001845704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001867819,"about_ca_topic_score_gemma":0.0002809431,"domain_scores_codex":[0.9998956,0.00002784028,0.000008796415,0.00001351541,0.00002443087,0.00002985243],"domain_scores_gemma":[0.9999175,0.000009789648,0.00002349295,0.000009643657,0.00000992336,0.00002970461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005110313,0.0001105004,0.0006484772,0.00006304316,0.000007315174,0.0001186146,0.00001176113,0.0000768421,0.9957879,0.0001145217,0.0001091669,0.002440749],"study_design_scores_gemma":[0.0002266627,0.003176431,0.02382139,0.00003270528,0.00006887829,0.0007555669,0.0001065379,0.002294911,0.963235,0.0004610845,0.005810133,0.00001078514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942777,0.002791209,0.001116027,0.000306491,0.00007352894,0.00002844502,0.0001118391,0.00008873039,0.001206183],"genre_scores_gemma":[0.9970254,0.000967839,0.0005416549,0.0001084495,0.00003846486,0.00001746875,0.00006473842,0.000007004022,0.001228925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00117349,"threshold_uncertainty_score":0.003925741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948573956487457,"score_gpt":0.2722501104196412,"score_spread":0.2527643708547666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}