{"id":"W3010044841","doi":"10.1016/j.cjca.2020.03.005","title":"Targeting Brain Aminopeptidase A: A New Strategy for the Treatment of Hypertension and Heart Failure","year":2020,"lang":"en","type":"review","venue":"Canadian Journal of Cardiology","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Genetic Engineering and Biotechnology; Fondation du Collège de France; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Medicine; Heart failure; Blood pressure; Angiotensin II; Angiotensin III; Blood–brain barrier; Prodrug; Myocardial infarction; Pharmacology; Renin–angiotensin system; Internal medicine; Angiotensin receptor; Central nervous system","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002679558,0.0002962882,0.003568118,0.0001990187,0.00009260689,0.00001349959,0.00009369707,0.00024187,0.00000305864],"category_scores_gemma":[0.0004729243,0.0001589714,0.0009179909,0.0001231754,0.0001581417,0.00001887886,0.000008783815,0.0002101545,0.000001905978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002077917,"about_ca_system_score_gemma":0.003053803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006109781,"about_ca_topic_score_gemma":0.0004179301,"domain_scores_codex":[0.9984522,0.0002096446,0.0007526273,0.0001986412,0.00009602721,0.0002907874],"domain_scores_gemma":[0.9977381,0.0007663023,0.0004767281,0.0001925074,0.0002792201,0.0005471951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004254812,0.000002538111,0.0003157014,0.001210983,0.003905369,0.0007194481,0.0002269066,0.00003485181,0.00002336727,0.00001783851,0.2816553,0.7118452],"study_design_scores_gemma":[0.0007811344,0.001813394,0.0002900444,0.002364114,0.003012389,0.006622205,0.0001454399,0.000002739191,9.922404e-7,0.000005127949,0.984855,0.00010744],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007006678,0.9934582,0.0001652768,0.004968062,0.0003218553,0.0009136804,0.00005563504,0.000002580959,0.00004465032],"genre_scores_gemma":[0.003101625,0.9931304,0.0004683223,0.0001248903,0.002989055,0.00001157959,0.00001600535,0.00004213824,0.0001159612],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7117377,"threshold_uncertainty_score":0.6482665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09119879014431725,"score_gpt":0.3116597541951516,"score_spread":0.2204609640508343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}