{"id":"W3010044841","doi":"10.1016/j.cjca.2020.03.005","title":"Targeting Brain Aminopeptidase A: A New Strategy for the Treatment of Hypertension and Heart Failure","year":2020,"lang":"en","type":"review","venue":"Canadian Journal of Cardiology","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Genetic Engineering and Biotechnology; Fondation du Collège de France; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Medicine; Heart failure; Blood pressure; Angiotensin II; Angiotensin III; Blood–brain barrier; Prodrug; Myocardial infarction; Pharmacology; Renin–angiotensin system; Internal medicine; Angiotensin receptor; Central nervous system","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008741706,0.0009926178,0.002616638,0.001699001,0.0002196403,0.00115556,0.001029683,0.001383032,0.003703957],"category_scores_gemma":[0.001167282,0.000237769,0.0008506419,0.001561148,0.0004889295,0.001169272,0.000603764,0.002722023,0.001162884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007506711,"about_ca_system_score_gemma":0.001759454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002644164,"about_ca_topic_score_gemma":0.00661539,"domain_scores_codex":[0.999791,0.00004030542,0.0000329079,0.00003672893,0.00007538444,0.00002364438],"domain_scores_gemma":[0.9994178,0.0003255303,0.00007927478,0.00000954748,0.0001157893,0.0000521527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003890989,0.0001137898,0.000216369,0.02247113,0.0004606474,0.0002455521,0.00002775485,0.0003257798,0.001549035,0.003072203,0.03325975,0.9378689],"study_design_scores_gemma":[0.0005828681,0.0005583962,0.002582902,0.01318519,0.00198839,0.001944996,0.0001091275,0.0004446577,0.000782321,0.004758819,0.972986,0.00007623031],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005505084,0.9993752,0.0000516963,0.000222135,0.00012958,0.000001701361,0.000009848155,0.000003668613,0.0001513111],"genre_scores_gemma":[0.0006481489,0.9986188,0.0001308632,0.0002602071,0.0001866567,0.000003856826,0.00001764352,8.228077e-7,0.0001329732],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003703957,"threshold_uncertainty_score":0.01239097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09119879014431725,"score_gpt":0.3116597541951516,"score_spread":0.2204609640508343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}