{"id":"W3010054583","doi":"10.1002/cjce.23743","title":"Therapeutic potential of a cell penetrating peptide (CPP, NP1) mediated siRNA delivery: Evidence in 3D spheroids of colon cancer cells","year":2020,"lang":"en","type":"article","venue":"The Canadian Journal of Chemical Engineering","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Spheroid; Transfection; Gene knockdown; RNA interference; Apoptosis; In vitro; Gene silencing; Small interfering RNA; Cell-penetrating peptide; Cell; Chemistry; Cell biology; Cancer research; Cell culture; Biology; RNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001391563,0.0001054623,0.00019216,0.00003981643,0.0000127174,0.000009806618,0.0003134546,0.00009093883,0.00003262898],"category_scores_gemma":[0.00007290188,0.00008883644,0.00008956975,0.0001197513,0.00005315193,0.000008693509,0.00002257141,0.0002069249,6.427894e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000385298,"about_ca_system_score_gemma":0.0004416944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001432027,"about_ca_topic_score_gemma":0.0005968488,"domain_scores_codex":[0.9992203,0.00002284567,0.000350535,0.00009711881,0.0001222623,0.0001869832],"domain_scores_gemma":[0.9994004,0.00003391871,0.0001670161,0.00009251095,0.0001324875,0.0001736116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006030511,0.000005197157,0.0003816801,0.00004775724,0.00003645982,0.00001198915,0.000183186,0.01549852,0.9834725,8.43814e-7,0.00007563943,0.0002259677],"study_design_scores_gemma":[0.0002502071,0.0001664044,0.0002028981,0.0001502128,0.00002969205,0.000008384932,0.00004551409,0.006984263,0.9920148,0.000002329615,0.00005658017,0.00008867871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961292,0.003328582,0.0002096827,0.0001715973,0.00007681779,0.00005452271,0.00001111705,0.000001129338,0.00001741804],"genre_scores_gemma":[0.9992748,0.0001520083,0.0002806436,0.0001426195,0.0001285624,0.000001386078,0.000002055073,0.00001289036,0.000004974947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008542379,"threshold_uncertainty_score":0.3622645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01516797784428989,"score_gpt":0.2103483538447904,"score_spread":0.1951803760005006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}