{"id":"W3010054583","doi":"10.1002/cjce.23743","title":"Therapeutic potential of a cell penetrating peptide (CPP, NP1) mediated siRNA delivery: Evidence in 3D spheroids of colon cancer cells","year":2020,"lang":"en","type":"article","venue":"The Canadian Journal of Chemical Engineering","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Spheroid; Transfection; Gene knockdown; RNA interference; Apoptosis; In vitro; Gene silencing; Small interfering RNA; Cell-penetrating peptide; Cell; Chemistry; Cell biology; Cancer research; Cell culture; Biology; RNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002216627,0.0003275106,0.0002681909,0.0001913722,0.0002328975,0.0002027419,0.0001208639,0.0003103192,0.0004997701],"category_scores_gemma":[0.0001029304,0.0001429871,0.0003039461,0.0001381202,0.0002614068,0.0001752307,0.0001261203,0.0003092991,0.0002517771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000328542,"about_ca_system_score_gemma":0.0002235419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004358341,"about_ca_topic_score_gemma":0.003371159,"domain_scores_codex":[0.9998719,0.0000334085,0.00001011987,0.0000304022,0.00003484951,0.00001943537],"domain_scores_gemma":[0.9998701,0.00004487852,0.00002325125,0.00002003382,0.00001963983,0.00002207771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003435357,0.00002452401,0.00009815575,0.00003519307,0.000004135958,0.00008236633,0.00003792583,0.0002136724,0.9987327,0.00003457682,0.00004689209,0.00065533],"study_design_scores_gemma":[0.000007838261,0.0003090545,0.002058022,0.000002657557,0.00001150684,0.0001836999,0.00002696553,0.001452302,0.9950542,0.00001727015,0.0008721755,0.000004222928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867125,0.001885214,0.008714219,0.0001615037,0.00004506448,0.00007703505,0.0005449249,0.0002066236,0.001653007],"genre_scores_gemma":[0.9912629,0.001024588,0.005665338,0.00004157377,0.000005672095,0.00006298974,0.0003585047,0.00003342471,0.001545027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004358341,"threshold_uncertainty_score":0.008665979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01516797784428989,"score_gpt":0.2103483538447904,"score_spread":0.1951803760005006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}