{"id":"W3010063823","doi":"10.1038/s41598-020-60861-2","title":"Photoinduced damage of AsLOV2 domain is accompanied by increased singlet oxygen production due to flavin dissociation","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"bioluminescence and chemiluminescence research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020 Framework Programme; Vedecká Grantová Agentúra MŠVVaŠ SR a SAV; Agentúra na Podporu Výskumu a Vývoja; Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky; University of Windsor","keywords":"Flavin mononucleotide; Flavin group; Singlet oxygen; Chemistry; Dissociation (chemistry); Photochemistry; Cofactor; Flavoprotein; Flavin adenine dinucleotide; Cysteine; Amino acid; Quenching (fluorescence); Oxygen; Biochemistry; Enzyme; Fluorescence; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000701681,0.0002658032,0.0001663557,0.0001133072,0.000113635,0.0001495271,0.0002486958,0.0002580691,0.001188249],"category_scores_gemma":[0.00008302593,0.00008164722,0.0002065934,0.0001331466,0.000152155,0.0001303552,0.0001309943,0.0003344013,0.0002109838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003205396,"about_ca_system_score_gemma":0.00007812898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089524,"about_ca_topic_score_gemma":0.000767034,"domain_scores_codex":[0.999912,0.00001091993,0.000007109608,0.00002506246,0.00002270941,0.00002202524],"domain_scores_gemma":[0.9998813,0.00001776151,0.00004570857,0.00001522825,0.00001008631,0.00002993222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004507617,0.000005284667,0.0001019916,0.000008931991,0.000001847957,0.00002701705,0.000005453314,0.00001404259,0.9996878,0.00001131192,0.000007757911,0.00008345306],"study_design_scores_gemma":[0.000005074201,0.00008388116,0.006308324,0.000001739257,0.000004410644,0.0001605487,0.00001961205,0.0004980161,0.9923636,0.00001672312,0.0005347597,0.000003413806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985518,0.0001750276,0.0007256392,0.00002449288,0.00001074802,0.000004396414,0.000264902,0.00002708032,0.0002159914],"genre_scores_gemma":[0.9978752,0.0000691308,0.0006533636,0.00001993486,0.000002649746,0.00000650399,0.0004845863,0.0000187765,0.0008699567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001188249,"threshold_uncertainty_score":0.003975093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01417521573564002,"score_gpt":0.2604461534898159,"score_spread":0.2462709377541759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}