{"id":"W3010102970","doi":"10.1038/s41598-020-60840-7","title":"Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; McMaster University; Bayer; University of Michigan; National Institute of General Medical Sciences; Novo Nordisk; American Heart Association; National Institutes of Health; Hemophilia of Georgia; National Hemophilia Foundation","keywords":"Zebrafish; Thrombin; Coagulation; Mutant; Biology; Fibrinogen; Mutation; Prothrombin time; Cell biology; Internal medicine; Medicine; Immunology; Genetics; Biochemistry; Platelet; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001294497,0.0005163904,0.0002193845,0.0004591313,0.0002712193,0.0002213957,0.0003040362,0.0005685732,0.00186401],"category_scores_gemma":[0.000180468,0.0002826464,0.0003731512,0.0001073678,0.0004329679,0.0002081173,0.000328792,0.0007510572,0.0005726364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006281249,"about_ca_system_score_gemma":0.0003938597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004185693,"about_ca_topic_score_gemma":0.006648367,"domain_scores_codex":[0.9998652,0.00001228869,0.00001768195,0.0000316627,0.00004410523,0.00002908502],"domain_scores_gemma":[0.9997919,0.00003259758,0.00008812342,0.00001547875,0.00001440474,0.000057571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006362161,0.00001028393,0.0001973301,0.00001949423,0.000004777007,0.0002998152,0.00003298113,0.0001413121,0.9982729,0.0001838284,0.00008721566,0.0006864166],"study_design_scores_gemma":[0.00009957422,0.0007694738,0.01700361,0.00003844768,0.00005593625,0.001994048,0.000116935,0.002948405,0.971936,0.0003381272,0.004665922,0.00003345582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903908,0.0006545298,0.00494408,0.0002729434,0.00005034933,0.00004816772,0.001070736,0.0002452617,0.002323267],"genre_scores_gemma":[0.98366,0.0006648749,0.003126139,0.0001272528,0.000009555033,0.00008480324,0.0007284555,0.0001031789,0.01149582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004185693,"threshold_uncertainty_score":0.008322656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04081699749585518,"score_gpt":0.2998635761324946,"score_spread":0.2590465786366395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}