{"id":"W3010105342","doi":"10.1200/jco.19.01265","title":"Activity of Vincristine and Irinotecan in Diffuse Anaplastic Wilms Tumor and Therapy Outcomes of Stage II to IV Disease: Results of the Children’s Oncology Group AREN0321 Study","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University; University of Alberta","funders":"National Cancer Institute","keywords":"Medicine; Irinotecan; Wilms' tumor; Vincristine; Oncology; Stage (stratigraphy); Internal medicine; Pediatric oncology; Disease; Anaplasia; Chemotherapy; Cancer; Pathology; Colorectal cancer; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008386719,0.0001307241,0.0009873423,0.00004983316,0.00002625923,0.000002069731,0.0002283738,0.0001750367,0.000003616514],"category_scores_gemma":[0.002440521,0.00007583918,0.0001822821,0.000117356,0.0003330133,0.000005798764,0.0002293693,0.0004022738,5.472048e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001973294,"about_ca_system_score_gemma":0.0004039937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008513471,"about_ca_topic_score_gemma":0.0002426236,"domain_scores_codex":[0.9976118,0.0005180457,0.001333894,0.0002283336,0.0001759505,0.0001319992],"domain_scores_gemma":[0.9973289,0.0004390554,0.001711556,0.0001703259,0.0001133125,0.0002368302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03436634,0.005716578,0.8775237,0.00004139482,0.0006504082,0.00005849441,0.0003921142,0.0002659375,0.03995127,0.000008290383,0.0002164207,0.04080902],"study_design_scores_gemma":[0.01127449,0.03545376,0.9491738,0.00002888284,0.00009225461,0.00000948229,0.0001090664,0.00003518638,0.002430931,0.00001250584,0.001301881,0.00007772772],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959768,0.000509442,0.0000134866,0.002954806,0.0001799249,0.0002783081,0.00005246027,0.000001005881,0.00003376628],"genre_scores_gemma":[0.9981851,0.001128957,0.00007611651,0.0004714166,0.0001078617,0.000002582798,0.00000141543,0.000008378591,0.00001815281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0716501,"threshold_uncertainty_score":0.3092632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04122866217729047,"score_gpt":0.3770713239223553,"score_spread":0.3358426617450648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}