{"id":"W3010105342","doi":"10.1200/jco.19.01265","title":"Activity of Vincristine and Irinotecan in Diffuse Anaplastic Wilms Tumor and Therapy Outcomes of Stage II to IV Disease: Results of the Children’s Oncology Group AREN0321 Study","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University; University of Alberta","funders":"National Cancer Institute","keywords":"Medicine; Irinotecan; Wilms' tumor; Vincristine; Oncology; Stage (stratigraphy); Internal medicine; Pediatric oncology; Disease; Anaplasia; Chemotherapy; Cancer; Pathology; Colorectal cancer; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003011083,0.0005700671,0.0007534397,0.0003442875,0.0003130522,0.0004972357,0.0004882558,0.0004420376,0.0005190614],"category_scores_gemma":[0.00171426,0.0002258102,0.001065817,0.0006938775,0.0004375456,0.0003375648,0.0003142111,0.0007949576,0.000100956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001285142,"about_ca_system_score_gemma":0.00140399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004006802,"about_ca_topic_score_gemma":0.008737988,"domain_scores_codex":[0.9983777,0.0008216382,0.0001049895,0.0001768046,0.0003826493,0.0001363114],"domain_scores_gemma":[0.996832,0.0006087095,0.001225262,0.000192404,0.0002277536,0.0009138209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04356543,0.004572161,0.9166589,0.0002209517,0.001611357,0.0003146288,0.0001889279,0.001437647,0.004775387,0.00009417083,0.001377708,0.02518262],"study_design_scores_gemma":[0.008003831,0.02465638,0.9614213,0.00003747941,0.0005383975,0.0005986181,0.00007547921,0.0007027386,0.001507669,0.00003453802,0.002406078,0.00001736636],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978845,0.0007621016,0.00006217183,0.0000885332,0.00001131395,0.0000909215,0.0005067834,0.00000298314,0.0005907041],"genre_scores_gemma":[0.9966753,0.0005187661,0.0002244235,0.0001200974,0.00003744406,0.0001403077,0.001957575,0.000004893905,0.0003212257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004006802,"threshold_uncertainty_score":0.01592427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04122866217729047,"score_gpt":0.3770713239223553,"score_spread":0.3358426617450648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}