{"id":"W3010137436","doi":"10.1093/jnci/djaa031","title":"Radiation Treatment, <i>ATM</i>, <i>BRCA1/2</i>, and <i>CHEK2</i>*1100delC Pathogenic Variants and Risk of Contralateral Breast Cancer","year":2020,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institutes of Health","keywords":"CHEK2; Breast cancer; Cancer; Oncology; Medicine; Internal medicine; Genetics; Biology; Mutation; Gene; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006356315,0.0002323397,0.0002416704,0.0006554851,0.0001901484,0.0003581232,0.000328106,0.0003685222,0.001206983],"category_scores_gemma":[0.002788064,0.000279026,0.0004950747,0.0005423548,0.0003287105,0.0001588498,0.0001896337,0.0003513009,0.0001083882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000223496,"about_ca_system_score_gemma":0.0001852701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005769129,"about_ca_topic_score_gemma":0.004535442,"domain_scores_codex":[0.9996278,0.0001194587,0.00003433305,0.000120171,0.00005120988,0.0000469715],"domain_scores_gemma":[0.998638,0.0003883394,0.000671685,0.0001488856,0.00004981343,0.0001034232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000357891,0.00002524098,0.9968143,0.00001047063,0.000133714,0.0001654393,0.00003178732,0.00009819207,0.000813676,0.00002132055,0.00004339684,0.001484594],"study_design_scores_gemma":[0.00001567552,0.0001622322,0.9978999,0.000005042409,0.0001337155,0.001015439,0.0000277563,0.0002720399,0.0003113018,0.00003453217,0.0001190379,0.000003312865],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992223,0.000289127,0.0001261867,0.00001656149,0.000003011255,0.000003742888,0.0000949508,0.000005860478,0.0002383596],"genre_scores_gemma":[0.9996302,0.00008730809,0.00007166046,0.00001344384,0.000007567326,0.00000282389,0.00008838461,0.000002095085,0.000096376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005769129,"threshold_uncertainty_score":0.01147109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01978403909642664,"score_gpt":0.2845798607182243,"score_spread":0.2647958216217977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}