{"id":"W3010148517","doi":"10.7554/elife.52539","title":"SLAMF6 deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Cancer Institute; National Institutes of Health; Azrieli Foundation; Israel Science Foundation; Deutsche Forschungsgemeinschaft; International Development Research Centre; Rosetrees Trust; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Canadian Institutes of Health Research; Melanoma Research Alliance","keywords":"Effector; Phenotype; Cell biology; Biology; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002031158,0.0001816998,0.0002262411,0.00005174164,0.000189078,0.0000343683,0.0001246174,0.0001128789,0.001033264],"category_scores_gemma":[0.0001490523,0.000167417,0.00006890703,0.0001000415,0.00004803347,0.0001665722,0.00007408297,0.000324739,0.001877428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003583658,"about_ca_system_score_gemma":0.00004244496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001309329,"about_ca_topic_score_gemma":0.000003066639,"domain_scores_codex":[0.9989012,0.00009316126,0.0003145483,0.000364601,0.0000523005,0.0002741933],"domain_scores_gemma":[0.9995344,0.00005384221,0.0001343366,0.0001541686,0.00006608022,0.00005712159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000255306,0.0001207448,0.0002165114,0.00004625394,0.00002476301,0.000002681332,0.002109727,0.00001810906,0.9932779,0.00007400548,0.003172703,0.0006812706],"study_design_scores_gemma":[0.002444534,0.001187495,0.001303994,0.00007160478,0.00007171289,0.00005565631,0.002222718,0.0005384801,0.8181774,0.000007408113,0.1735032,0.0004157289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883509,0.001571112,0.002754269,0.0007728554,0.0023813,0.0002750242,0.000005141876,0.0001268163,0.00376259],"genre_scores_gemma":[0.9937066,0.00006762752,0.0002777884,0.004011216,0.0001031398,0.00001272336,0.00008241988,0.00002328033,0.001715154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1751005,"threshold_uncertainty_score":0.99988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02708210730423083,"score_gpt":0.2530104197720482,"score_spread":0.2259283124678174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}