{"id":"W3010150364","doi":"10.1016/j.jpba.2020.113230","title":"Quantitation of polymeric-microneedle-delivered HA15 in tissues using liquid chromatography-tandem mass spectrometry","year":2020,"lang":"en","type":"article","venue":"Journal of Pharmaceutical and Biomedical Analysis","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Cape Breton University","funders":"China Postdoctoral Science Foundation; Canada Research Chairs; Beatrice Hunter Cancer Research Institute","keywords":"Chemistry; Chromatography; Detection limit; Ex vivo; Liquid chromatography–mass spectrometry; Mass spectrometry; Protein precipitation; In vivo; Tandem mass spectrometry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004245234,0.0004984297,0.0002502734,0.0005876312,0.0004277897,0.0005050481,0.0003893957,0.0006161172,0.000839396],"category_scores_gemma":[0.0004123089,0.0002098431,0.0002758027,0.0003137214,0.0004312274,0.000469084,0.0002356257,0.0006078884,0.000445461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006141166,"about_ca_system_score_gemma":0.0007163583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002107083,"about_ca_topic_score_gemma":0.003757364,"domain_scores_codex":[0.999656,0.00003601672,0.00002229581,0.0001263748,0.0001146163,0.00004471565],"domain_scores_gemma":[0.9997471,0.00007855587,0.00004340307,0.00002561346,0.00007344116,0.00003188053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004260706,0.00001775629,0.000239999,0.0000213365,0.000007058841,0.00001521668,0.00001590825,0.00003854741,0.9975134,0.00006020621,0.00002691138,0.002001157],"study_design_scores_gemma":[0.000003788499,0.00009048715,0.003497994,0.000005805834,0.00001226106,0.00007883771,0.00002424472,0.001302814,0.9940034,0.00005235337,0.0009225003,0.000005602212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.892662,0.007402011,0.09161124,0.0003375518,0.0002244083,0.0002741156,0.001297707,0.0008680567,0.005322921],"genre_scores_gemma":[0.8758078,0.003519717,0.106245,0.0007346347,0.00005617723,0.000465073,0.001439978,0.0001279772,0.01160356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002107083,"threshold_uncertainty_score":0.004455805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.10038477899555,"score_gpt":0.4320536154810806,"score_spread":0.3316688364855306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}